Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kelsey Keith"'
Autor:
Ang Sun, Pyounghwa Park, Lauren Cole, Himani Vaidya, Shinji Maegawa, Kelsey Keith, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
DNA methylation is an epigenetic process altered in cancer and ageing. Age-related methylation drift can be used to estimate lifespan and can be influenced by extrinsic factors such as diet. Here, we report that non-pathogenic microbiota accelerate a
Externí odkaz:
https://doaj.org/article/0d76cdc134c84fa5b279afe1435cdddd
Autor:
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology of how this occurs is still unexplained. We analyze DNA methylation with age in mouse int
Externí odkaz:
https://doaj.org/article/f5d8cc73b5694855b70f542f7cf5d21c
Autor:
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cyt
Externí odkaz:
https://doaj.org/article/6a1e68a25f2743b5ba8846d77af44340
Autor:
Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating
Externí odkaz:
https://doaj.org/article/2856375f622b4bc5bda4e07109ea89fe
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogen
Externí odkaz:
https://doaj.org/article/08d60dfa06354f1792c694cb232b3b9d
Autor:
Sarah M. Morgan, Hideki Tanizawa, Lisa Beatrice Caruso, Michael Hulse, Andrew Kossenkov, Jozef Madzo, Kelsey Keith, Yinfei Tan, Sarah Boyle, Paul M. Lieberman, Italo Tempera
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Genome folding in the nucleus plays an important role in regulating gene expression. Here the authors show that 3D genome architecture also plays an important role for gene expression adaptability for the Epstein-Barr Virus (EBV), a virus that is ass
Externí odkaz:
https://doaj.org/article/424a49de5634470e8123f77694842c45
Autor:
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/bd9a6a03ad7940e3b37dfc96cbecbf2d
Autor:
Shoghag Panjarian, Jozef Madzo, Kelsey Keith, Carolyn M. Slater, Carmen Sapienza, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA methylation alterations and used those methylation sites to identify ind
Externí odkaz:
https://doaj.org/article/5cb2272a37a4423e82b77f220b34343d
Autor:
Lisa Beatrice Caruso, Rui Guo, Kelsey Keith, Jozef Madzo, Davide Maestri, Sarah Boyle, Jason Wasserman, Andrew Kossenkov, Benjamin E. Gewurz, Italo Tempera
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals. In latently in
Externí odkaz:
https://doaj.org/article/5dc97abd85824706a7f8e1e15248ec51
Autor:
Tomasz Skorski, Grant A. Challen, Neil Johnson, Katarzyna Piwocka, Italo Tempera, George S. Vassiliou, Giovanni Martinelli, Jian Huang, Mark D. Minden, Mark R. Litzow, Hugo F. Fernandez, Martin S. Tallman, Elisabeth M. Paietta, Peter Valent, Stephen M. Sykes, Georg Greiner, Giorgia Simonetti, Daniela Di Marcantonio, Ksenia Matlawska-Wasowska, Boris A. Bartholdy, Kumaraswamy N. Chitrala, Antonella Padella, Zhaorui Lian, Zachary Gazze, Lisa Beatrice Caruso, Jozef Madzo, Kelsey Keith, Michael Hulse, Joseph Nacson, Wangisa M.B. Dunuwille, Katherine Sullivan-Reed, Konstantin Golovine, Margaret Nieborowska-Skorska, Bac Viet Le, Silvia Maifrede
Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbb1df0a7c02d673032e64a0cd119330
https://doi.org/10.1158/0008-5472.c.6513157.v1
https://doi.org/10.1158/0008-5472.c.6513157.v1