Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kelsey E. Sivick"'
Autor:
Erik Van Dis, Kimberly M. Sogi, Chris S. Rae, Kelsey E. Sivick, Natalie H. Surh, Meredith L. Leong, David B. Kanne, Ken Metchette, Justin J. Leong, Jacob R. Bruml, Vivian Chen, Kartoosh Heydari, Nathalie Cadieux, Tom Evans, Sarah M. McWhirter, Thomas W. Dubensky, Jr., Daniel A. Portnoy, Sarah A. Stanley
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1435-1447 (2018)
Summary: There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein su
Externí odkaz:
https://doaj.org/article/5af82e8c90b24ca6bea46b4f64e9ab0e
Autor:
Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, Gabrielle L. Reiner, Leticia Corrales, Natalie H. Surh, Thomas E. Hudson, Uyen T. Vu, Brian J. Francica, Tamara Banda, George E. Katibah, David B. Kanne, Justin J. Leong, Ken Metchette, Jacob R. Bruml, Chudi O. Ndubaku, Jeffrey M. McKenna, Yan Feng, Lianxing Zheng, Steven L. Bender, Charles Y. Cho, Meredith L. Leong, Andrea van Elsas, Thomas W. Dubensky, Jr., Sarah M. McWhirter
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3074-3085.e5 (2018)
Summary: Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is us
Externí odkaz:
https://doaj.org/article/6640eed869a2425eb7c9442fb0d88d76
Autor:
Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter, David B. Kanne, Kelsey E. Sivick, George E. Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J. Leong, Ken Metchette, Thomas W. Dubensky Jr., Thomas F. Gajewski
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 1018-1030 (2015)
Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-resident dendritic cells. On the basis of recent observations indicating that IFN-β expression was dependent upon activation of the host STING pathway, we hypothes
Externí odkaz:
https://doaj.org/article/09b15c62c7fe4563b675d2d57fcdb686
Autor:
Paul Foster, Amita Patnaik, Lisa Seitz, Dana Piovesan, Soonweng Cho, Xiaoning Zhao, Amy E Anderson, Nigel Walker, Hema Singh, Casey G Mitchell, Matthew J Walters, Kelsey E Sivick Gauthier, Amber E de Groot, Rebecca D Ray, Nina K Serwas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/10611e68676a41a18ee0431cb913124e
Autor:
Ning Wang, Sean Cho, Dana Piovesan, Cesar Meleza, Patrick G Schweickert, Gabrielle L Reiner, Casey G Mitchell, Juan Jose Fung, Jeremy Fournier, Matthew J Walters, Kelsey E Sivick Gauthier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/2c126220155e4a05b4e6fa603aec1da7
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a915ee7bfe3efd5944b3b40db828628
https://doi.org/10.1158/2326-6066.22540031.v1
https://doi.org/10.1158/2326-6066.22540031.v1
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
S1: Timeline of necrosis after CDN injection. S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes. S3: B16F10 is not directly killed by CDN exposure and behaves similarly to other mouse and human cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ac9846b27c83bca6e21a030b23fe47
https://doi.org/10.1158/2326-6066.22540019.v1
https://doi.org/10.1158/2326-6066.22540019.v1
Autor:
Matthew J. Walters, Kelsey E. Sivick, Uli Schindler, Jay P. Powers, Stephen W. Young, Jaroslaw Kalisiak, Nikki Kimura, Timothy W. Park, Bhamini Purandare, Susan L. Paprcka, Fangfang Yin, Akshata R. Udyavar, Elaine Ginn, Ada Chen, Kristen Zhang, Daniel DiRenzo, Nell Narasappa, Jesus Banuelos, Annette Becker, Joanne B.L. Tan, Dana Piovesan
Supplementary Data from Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb5b5a4e6987b75f7ac46778faa4a20
https://doi.org/10.1158/1535-7163.22522347
https://doi.org/10.1158/1535-7163.22522347
Autor:
Matthew J. Walters, Kelsey E. Sivick, Uli Schindler, Jay P. Powers, Stephen W. Young, Jaroslaw Kalisiak, Nikki Kimura, Timothy W. Park, Bhamini Purandare, Susan L. Paprcka, Fangfang Yin, Akshata R. Udyavar, Elaine Ginn, Ada Chen, Kristen Zhang, Daniel DiRenzo, Nell Narasappa, Jesus Banuelos, Annette Becker, Joanne B.L. Tan, Dana Piovesan
Supplementary Figure from Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35adf1efc1bd618059ec8b92f7b406e6
https://doi.org/10.1158/1535-7163.22522341
https://doi.org/10.1158/1535-7163.22522341
Autor:
Charles G. Drake, Drew M. Pardoll, Thomas W. Dubensky, Sarah M. McWhirter, Meredith L. Leong, Andrew B. Sharabi, Ariel E. Marciscano, Laura Hix Glickman, Gabrielle L. Reiner, Kelsey E. Sivick, Debebe Theodros, Anthony L. Desbien, Ali Ghasemzadeh, Brian J. Francica
The cGAS–STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509df28f14c303f465adcdc06aad30ad
https://doi.org/10.1158/2326-6066.c.6549257
https://doi.org/10.1158/2326-6066.c.6549257