Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kelsey E. Huntington"'
Autor:
Tej Tummala, Ashley Sanchez Sevilla Uruchurtu, Arielle De La Cruz, Kelsey E. Huntington, Andrew George, Nicholas R. Liguori, Leiqing Zhang, Lanlan Zhou, Abbas E. Abbas, Christopher G. Azzoli, Wafik S. El-Deiry
Publikováno v:
Current Oncology, Vol 30, Iss 11, Pp 9611-9626 (2023)
Pancreatic cancer is a devastating disease with a poor prognosis. Novel chemotherapeutics in pancreatic cancer have shown limited success, illustrating the urgent need for new treatments. Lurbinectedin (PM01183; LY-01017) received FDA approval in 202
Externí odkaz:
https://doaj.org/article/baef67e61ff84cad80cfd50ebbb42934
Autor:
Hongwei Yao, Joselynn Wallace, Abigail L. Peterson, Alejandro Scaffa, Salu Rizal, Katy Hegarty, Hajime Maeda, Jason L. Chang, Nathalie Oulhen, Jill A. Kreiling, Kelsey E. Huntington, Monique E. De Paepe, Guilherme Barbosa, Phyllis A. Dennery
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Senescence causes age-related diseases and stress-related injury, but it is also physiologically essential during development. Here, Yao et al. show that programmed senescence in mesenchymal cells orchestrates postnatal lung development and that neon
Externí odkaz:
https://doaj.org/article/94d3d8e53fda4b72bd522888728ef658
Autor:
Andrew Hsu, Kelsey E. Huntington, Andre De Souza, Lanlan Zhou, Adam J. Olszewski, Nirav P. Makwana, Diana O. Treaba, Ludimila Cavalcante, Francis J. Giles, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 417-423 (2022)
GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell functi
Externí odkaz:
https://doaj.org/article/92cb5ee1490243b8bd245afdd67c0799
Autor:
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. Huntington, Monique E. De Paepe, Phyllis A. Dennery
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. We and others have sh
Externí odkaz:
https://doaj.org/article/0d9e7f9b2e284b31bb7a4fb788228de5
Autor:
Jeffrey T. McNamara, Kelsey E. Huntington, Samantha Borys, Chathuraka T. Jayasuriya, Laurent Brossay
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartil
Externí odkaz:
https://doaj.org/article/9a751a04443e4a1ea1e610f1904326ef
Autor:
Kelsey E. Huntington, Anna D. Louie, Praveen R. Srinivasan, Christoph Schorl, Shaolei Lu, David Silverberg, Daniel Newhouse, Zhijin Wu, Lanlan Zhou, Brittany A. Borden, Francis J. Giles, Mark Dooner, Benedito A. Carneiro, Wafik S. El-Deiry
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10870 (2023)
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that has been implicated in numerous oncogenic processes. GSK-3 inhibitor elraglusib (9-ING-41) has shown promising preclinical and clinical antitumor activity across multiple tumor type
Externí odkaz:
https://doaj.org/article/5b4bc7b6e2544d4e950318211b22c22c
Autor:
Kelsey E. Huntington, Lindsey Carlsen, Eui-Young So, Matthias Piesche, Olin Liang, Wafik S. El-Deiry
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 618 (2022)
As COVID-19 continues to pose major risk for vulnerable populations, including the elderly, immunocompromised, patients with cancer, and those with contraindications to vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects t
Externí odkaz:
https://doaj.org/article/21cb98cf794349dd9c1d705377333217
Autor:
Kelsey E Huntington, Anna D Louie, Chun Geun Lee, Jack A Elias, Eric A Ross, Wafik S El-Deiry
Publikováno v:
eLife, Vol 10 (2021)
Although the range of immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is variable, cytokine storm is observed in a subset of symptomatic individuals. To further understand the disease pathogenesis and, consequently, t
Externí odkaz:
https://doaj.org/article/227f3343cf834c569cb2cbdd08f31db4
Autor:
Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry
Publikováno v:
Biochemical Society Transactions. 51:57-70
The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches
Autor:
El-Deiry, Kelsey E. Huntington, Anna D. Louie, Praveen R. Srinivasan, Christoph Schorl, Shaolei Lu, David Silverberg, Daniel Newhouse, Zhijin Wu, Lanlan Zhou, Brittany A. Borden, Francis J. Giles, Mark Dooner, Benedito A. Carneiro, Wafik S.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10870
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that has been implicated in numerous oncogenic processes. GSK-3 inhibitor elraglusib (9-ING-41) has shown promising preclinical and clinical antitumor activity across multiple tumor type