Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Autor: Kathryn E. Livingston, Shainnel O. Eans, Andrew D. White, Neil T. Burford, Jay P. McLaughlin, Bernard P. Roques, Andrew Alt, Todd M. Hillhouse, Ram Kandasamy, Minghua Li, Susan L. Ingram, Claire Meurice, Kelsey E Kochan, John R. Traynor

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (16), pp.e2000017118. ⟨10.1073/pnas.2000017118⟩

International audience; Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on the idea that PAMs will promote the action of endogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592cc679812be187baac01d7115fa3bf
https://europepmc.org/articles/PMC8072371/

In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration

Autor: Jessica P, Anand, Kelsey E, Kochan, Anthony F, Nastase, Deanna, Montgomery, Nicholas W, Griggs, John R, Traynor, Henry I, Mosberg, Emily M, Jutkiewicz

Publikováno v: British journal of pharmacology. 175(11)

BACKGROUND AND PURPOSE: Agonists at μ‐opioid receptors (μ‐receptors) are used for pain management but produce adverse effects including tolerance, dependence and euphoria. The co‐administration of a μ‐receptor agonist with a δ‐opioid re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28125a02c42cbdd344b119d69c09dd46
https://pubmed.ncbi.nlm.nih.gov/29352503