Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kelsey Bohn"'
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224081 (2019)
Steroid hormones and their respective nuclear receptors are essential mediators in numerous physiologic and pathophysiologic processes, ranging from regulation of metabolism, immune function, and reproductive processes to the development of hormone-d
Externí odkaz:
https://doaj.org/article/fc38b79f00c646ed98ab7326ac3146d8
Autor:
Kelsey Bohn, Neha Agrawal, Jean Chmielewski, Meghan E. Willoughby, Christine A. Hrycyna, Hilda A. Namanja-Magliano
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5128-5132
The brain provides a sanctuary site for HIV due, in part, to poor penetration of antiretroviral agents at the blood-brain barrier. This lack of penetration is partially attributed to drug efflux transporters such as P-glycoprotein (P-gp) and ABCG2. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46af1186a118eb0daa5ade6b192ae8a0
https://doi.org/10.1016/j.bmc.2017.07.001
https://doi.org/10.1016/j.bmc.2017.07.001
Publikováno v:
Molecular Pharmaceutics. 14:1107-1119
Many atypical antipsychotic drugs currently prescribed for the treatment of schizophrenia have limited brain penetration due to the efflux activity of ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB), including P-glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6680237da2f661eebd43dedae2499fa5
https://doi.org/10.1021/acs.molpharmaceut.6b01044
https://doi.org/10.1021/acs.molpharmaceut.6b01044
Autor:
Hilda A. Namanja, Frances J. Sharom, Dana Emmert, David S. Miller, Christine A. Hrycyna, Christopher R. Campos, David G. Ward, Jean Chmielewski, Kelsey Bohn, Peihua Lu
Publikováno v:
ACS Chemical Neuroscience. 5:305-317
The multidrug resistance transporter P-glycoprotein (P-gp) is highly expressed in the capillary endothelial cells of the blood-brain barrier (BBB) where it functions to limit the brain penetration of many drugs, including antipsychotic agents used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f45c4ba88d000a751de0464df1c01
https://doi.org/10.1021/cn4002329
https://doi.org/10.1021/cn4002329
Autor:
Robert L. Summers, Adele M. Lehane, Michael T. Ferdig, Rowena E. Martin, David A. Fidock, Marcos M. Pires, Hilda A. Namanja, Kelsey Bohn, Kiaran Kirk, Philipp P. Henrich, Christine A. Hrycyna, Jerrin Kuriakose, Jean Chmielewski
Publikováno v:
ACS Chemical Biology. 9:722-730
Chloroquine (CQ) resistance in the human malaria parasite Plasmodium falciparum is primarily conferred by mutations in the "chloroquine resistance transporter" (PfCRT). The resistance-conferring form of PfCRT (PfCRT(CQR)) mediates CQ resistance by ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372555d17a11442a6f492045a7f4de55
https://doi.org/10.1021/cb4008953
https://doi.org/10.1021/cb4008953
Activating mutations of human K-Ras proteins are among the most common oncogenic mutations, present in approximately 30% of all human cancers. Posttranslational modifications to K-Ras guide it to the plasma membrane and disruption of this localizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe72aaefdc7df4a73c70b77cd654165
https://europepmc.org/articles/PMC4990076/
https://europepmc.org/articles/PMC4990076/
Autor:
Jenq-Kuen Huang, Lisa Wen, Yam N Timsina, Kelsey Bohn, Ashish K. Pathak, Jennifer N Chmielowski, Phanichand Kodali
Publikováno v:
Protein Expression and Purification. 65:83-91
Francisella tularensis is an extremely infectious airborne pathogen that has long been considered as a potential biological weapon. Enzymes of fatty acid synthesis (FAS) pathway are attractive targets for the development of new antibacterial agents b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a88fd0fc46c15c07718557ffefb3fc9
https://doi.org/10.1016/j.pep.2008.11.011
https://doi.org/10.1016/j.pep.2008.11.011
Autor:
Lisa Wen, Yam N Timsina, Kelsey Bohn, Jennifer N Chmielowski, Jenq-Kuen Huang, Ashish K. Pathak, Phani C Chand
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75d1b08c659b456d435e58b57a0ac06
https://doi.org/10.1096/fasebj.23.1_supplement.675.1
https://doi.org/10.1096/fasebj.23.1_supplement.675.1
Autor:
Jennifer N Chmielowski, Ashish K. Pathak, Kelsey Bohn, Phani C Chand, Jenq-Kuen Huang, Lisa Wen, Yam N Timsina
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf96231f33e785afd76abd6dbf89abe
https://doi.org/10.1096/fasebj.23.1_supplement.675.2
https://doi.org/10.1096/fasebj.23.1_supplement.675.2