Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kelsey A. Trieger"'
Autor:
Warren C. Chan, Kelsey A. Trieger, James J. La Clair, Catriona H. M. Jamieson, Michael D. Burkart
Publikováno v:
Journal of Medicinal Chemistry. 66:6577-6590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22eaa442c03a6c6c799945446c7fbe01
https://doi.org/10.1021/acs.jmedchem.2c01893
https://doi.org/10.1021/acs.jmedchem.2c01893
Publikováno v:
Adv Healthc Mater
Extracellular glycans, such as glycosaminoglycans (GAGs), provide an essential regulatory component during the development and maintenance of tissues. GAGs, which harbor binding sites for a range of growth factors and other morphogens, help establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73693cb7c82b31f982a96a609d8e0edb
https://doi.org/10.1101/2021.06.19.448747
https://doi.org/10.1101/2021.06.19.448747
Publikováno v:
ACS Chem Biol
While recognized as a therapeutic target, the spliceosome may offer a robust vector to improve established therapeutics against other protein targets. Here, we describe how modulating the spliceosome using small molecule splice modulators (SPLMs) can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3f857d9dabc7cf194d4458503f4d96
https://pubmed.ncbi.nlm.nih.gov/32004428
https://pubmed.ncbi.nlm.nih.gov/32004428
Autor:
Catriona Jamieson, Martijn Q. Slagt, Minze T. Rispens, Michael D. Burkart, Dominika U. Bachera, Vincent L. de Boer, Pieter Hiemstra, Kelsey A Trieger, Remco M. Hofman, Warren C. W. Chan, James J. La Clair, Kyle A. Mandla, Joshua S. Figueroa, Rutger F. Bus, Mark T. Verhaar, Michael L. Neville, Rory van der Hulst, Brian León
Publikováno v:
Cell Reports Physical Science. 1:100277
Summary While splice modulators have entered clinical trials, limited clinical efficacy in splicing factor mutation-driven malignancies, such as acute myeloid leukemia, has remained a challenge. There is a pressing unmet medical need for developing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a2e2b6d44b7d8cf0c25d367b83c1d4
https://doi.org/10.1016/j.xcrp.2020.100277
https://doi.org/10.1016/j.xcrp.2020.100277