Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kellye C. Kirkbride"'
Autor:
Daisuke Hoshino, Kellye C. Kirkbride, Kaitlin Costello, Emily S. Clark, Seema Sinha, Nathan Grega-Larson, Matthew J. Tyska, Alissa M. Weaver
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1159-1168 (2013)
Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretio
Externí odkaz:
https://doaj.org/article/e4a3828e7fdb4653831da97bdd8e724b
Autor:
Catherine E. Gatza, Alisha. Holtzhausen, Kellye C. Kirkbride, Allyson. Morton, Michael L. Gatza, Michael B. Datto, Gerard C. Blobe
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 758-770 (2011)
The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging roles in regulating TGF-β superfamily signaling and cancer progression. Alterations in TGF-β superfamily signaling are common in colon cancer; how
Externí odkaz:
https://doaj.org/article/48ef2d21b6f34b538e3d505460dd02fe
Autor:
Meredith A. Jackson, Todd D. Giorgio, Thomas A. Werfel, Kellye C. Kirkbride, Martina Miteva, Taylor E. Kavanaugh, Craig L. Duvall
Publikováno v:
Journal of Controlled Release. 255:12-26
A rationally-designed library of ternary siRNA polyplexes was developed and screened for gene silencing efficacy in vitro and in vivo with the goal of overcoming both cell-level and systemic delivery barriers. [2-(dimethylamino)ethyl methacrylate] (D
Autor:
Nathan E. Grega-Larson, Motoharu Seiki, Seema Sinha, Daisuke Hoshino, Matthew J. Tyska, Alissa M. Weaver, Kellye C. Kirkbride, Nan Hyung Hong
Publikováno v:
The Journal of Cell Biology
Sinha et al. show that the cytoskeletal and tumor-overexpressed protein cortactin promotes secretion of exosomes from cancer cells by stabilizing dynamic cortical actin docking sites for multivesicular endosomes, suggesting a potential mechanism by w
Autor:
Julia Zaias, Darren Orton, Marcy L. Guerra, Zhiqiang Wang, Kellye C. Kirkbride, Xi Chen, Thomas Doundoulakis, Ethan Lee, Dao M. Nguyen, Floriano Marchetti, Dennis Liang Fei, Ke Jin, Jun Long, Laurence R. Sands, Melanie H. Cobb, Jezabel Rodriguez-Blanco, Anthony J. Capobianco, Chen Shen, Curtis A. Thorne, David J. Robbins, Maria T. Abreu, Leif R. Neitzel, Luisana Astudillo, Bin Li
Publikováno v:
Science Signaling. 10
Constitutive WNT activity drives the growth of various human tumors, including nearly all colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently approved for use in the clinic largely due to the small number of dr
Autor:
Kellye C. Kirkbride, Kevin J. Polach, Samantha J. Braxton, Megan D. Hoeksema, Dustin C. Rogers, Patricia Ladd-Ward, Durdica Vojnic Zelic, Santosh Putta, Matt Westfall, Norman Purvis
Publikováno v:
Cancer Research. 79:294-294
Pierian Biosciences has developed the ChemoINTEL platform for high-throughput, semi-automated quantification of cellular responses to chemotherapeutics. ChemoINTEL relies on a microscopy-based process that captures and analyzes single cell behavior t
Publikováno v:
Molecular Biology of the Cell. 20:4362-4370
Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors activin-like kinase (ALK)3 and ALK6 share a high degree of homology, yet
Autor:
Wendell G. Yarbrough, Brian B. Burkey, Michelle Q. Pham, James L. Netterville, Brandee T. Brown, Dan Liu, Amy S. Whigham, Pamela S. Wirth, Kellye C. Kirkbride, Robert J. Sinard, Sangeetha Vadivelu, Jonathan H. Law
Publikováno v:
The Laryngoscope. 119:2315-2323
Objectives/Hypothesis: To develop a reliable modeling system for head and neck squamous cell carcinoma (HNSCC). Study Design: Laboratory-based translational study. Methods: HNSCC tissue was obtained from patients at biopsy/resection, cultured, and im
Publikováno v:
Carcinogenesis. 30:238-248
Bone morphogenetic proteins (BMPs) have an emerging role in human cancers. Here we demonstrate that the BMP-signaling pathway is intact and functional in human pancreatic cancer cells, with several BMP signaling components and transcriptional targets
Autor:
Tam How, Nadine Hempel, Mei Dong, Kellye C. Kirkbride, Patrick J. Kelly, Jason D. Lee, Kelly J. Gordon, Gerard C. Blobe, Benjamin J. Moeller, Jeffrey R. Marks
Publikováno v:
Journal of Clinical Investigation. 117:206-217
The TGF-beta signaling pathway has a complex role in regulating mammary carcinogenesis. Here we demonstrate that the type III TGF-beta receptor (TbetaRIII, or betaglycan), a ubiquitously expressed TGF-beta coreceptor, regulated breast cancer progress