Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kelly Z Young"'
Autor:
Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108986- (2024)
Summary: Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in human keratinocytes through the epidermal type I IFN; IFN-κ. HERC6 knockdown in hum
Externí odkaz:
https://doaj.org/article/87cba07b11fb49b59bbc593a99230d5e
Autor:
Kelly Z. Young, BA, Naomi F. Briones, MD, MAT, Elisabeth A. Pedersen, MD, PhD, Douglas Fullen, MD, Frank Wang, MD
Publikováno v:
JAAD Case Reports, Vol 31, Iss , Pp 49-52 (2023)
Externí odkaz:
https://doaj.org/article/43e17cc64231400b8905e3a0750bf918
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a
Externí odkaz:
https://doaj.org/article/124e368074fe4cb093cf877c264102a0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that can manifest with abscesses, sinus tracts, and scarring in the intertriginous areas of the body. HS is characterized by immune dysregulation, featuring elevated levels of mye
Externí odkaz:
https://doaj.org/article/72dd43c8d0a14e73bd6f4060e8931310
Autor:
Kelly Z. Young, Carolina Rojas Ramírez, Simon G. Keep, John R. Gatti, Soo Jung Lee, Xiaojie Zhang, Magdalena I. Ivanova, Brandon T. Ruotolo, Michael M. Wang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific cysteine residue alterations and quaternary structures are induced by CADASIL mutations in NOTCH3, which are found to induce oligomeric states, altered disulphide bonding, increased free thiols and reduced protein stability.
Externí odkaz:
https://doaj.org/article/60e1780b1a8f414998df307a93fc4f7e
Autor:
Soo Jung Lee, Akhil Kondepudi, Kelly Z Young, Xiaojie Zhang, Naw May Pearl Cartee, Jijun Chen, Krystal Yujin Jang, Gang Xu, Jimo Borjigin, Michael M Wang
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281094 (2023)
The most common inherited cause of vascular dementia and stroke, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is caused by mutations in NOTCH3. Post-translationally altered NOTCH3 accumulates i
Externí odkaz:
https://doaj.org/article/a7b0fc3052af4bf6ba28219087b29fed
Publikováno v:
JAAD International, Vol 10, Iss , Pp 34-35 (2023)
Externí odkaz:
https://doaj.org/article/0e379e5d296d440e81cdea85174dc7aa
Publikováno v:
International Journal of Women's Dermatology, Vol 8, Iss 3, p e061 (2022)
Externí odkaz:
https://doaj.org/article/24d3d86957dc4520a683066b4d8e1e22
Autor:
Kelly Z. Young, BA, Sara L. Fossum, MD, PhD, Lori Lowe, MD, Tobias Else, MD, Leslie A. Fecher, MD, Hakan Demirci, MD, Kelly B. Cha, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 6, Iss 6, Pp 563-566 (2020)
Externí odkaz:
https://doaj.org/article/a995474b3ca64ffe8e3d7ab477e635fa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3671 (2022)
Cysteine oxidation states of extracellular proteins participate in functional regulation and in disease pathophysiology. In the most common inherited dementia, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Externí odkaz:
https://doaj.org/article/285299e2db0544cdb6ad5ce06037cc75