Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kelly W. Beers"'
Autor:
Theresa J. Berndt, Kelly W. Beers, Franklyn G. Knox, Michael A. Thompson, Gertrude M. Tyce, Frederico G. S. de Toledo, Thomas P. Dousa
Publikováno v:
Kidney International. 52:152-156
Opposite paracrine effects of 5-HT and dopamine on Na + -Pi cotransport in opossum kidney cells. Serotonin (5-HT) was recently reported to inhibit cAMP generation in oppossum (OK) cells. We thus investigated the effects of 5-HT upon the Na + -Pi cotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e76543b4f52ece04838b63c9d66b49
https://doi.org/10.1038/ki.1997.314
https://doi.org/10.1038/ki.1997.314
Autor:
John G. Ball, Gary O. Rankin, Suk K. Hong, Dianne K. Anestis, Monica A. Valentovic, John L. Hubbard, Patrick I. Brown, Kelly W. Beers, Derek W. Nicoll
Publikováno v:
Toxicology. 108:109-123
Nephrotoxicity occurs following intraperitoneal (i.p.) administration of 2-chloroaniline or 4-chloroaniline hydrochloride to Fischer 344 rats, but the nephrotoxicant chemical species and mechanism of nephrotoxicity are unknown. The purpose of this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95cf62d68286f94d0fe970caec0696e
https://doi.org/10.1016/0300-483x(95)03294-p
https://doi.org/10.1016/0300-483x(95)03294-p
Publikováno v:
Biochemical and Biophysical Research Communications. 221:442-445
Estrogens play a major role in mineral homeostasis, however it remains unclear whether they exert regulatory action upon reabsorption of phosphate (P i ) in proximal tubules of the kidney. We investigated the effect of β-estradiol (E 2 ) injected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8df4e606ff8edc363ab170dbbd10ef
https://doi.org/10.1006/bbrc.1996.0614
https://doi.org/10.1006/bbrc.1996.0614
Publikováno v:
American Journal of Physiology-Cell Physiology. 269:C1042-C1047
Cyclic ADP-ribose (cADPR) is a potent mediator of Ca2+ mobilization from intracellular stores in sea urchin eggs. However, the regulation of the cADPR-induced Ca2+ release system is not yet fully elucidated. We now report that spermine and related po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3fa10b01d48348e2ba347fbbfeeb7
https://doi.org/10.1152/ajpcell.1995.269.4.c1042
https://doi.org/10.1152/ajpcell.1995.269.4.c1042
Publikováno v:
Journal of Clinical Investigation. 95:2385-2390
Cyclic adenosine diphospho-ribose (cADPR) triggers Ca2+ release from intracellular stores and is therefore proposed to function as a second messenger in cellular signaling; however, an extracellular stimulus, i.e., first messenger (hormone or autacoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65060bcc347051b9c08973f79d60d0de
https://doi.org/10.1172/jci117932
https://doi.org/10.1172/jci117932
Publikováno v:
American Journal of Physiology-Cell Physiology. 268:C741-C746
We have previously shown that NAD+ inhibits renal Na(+)-Pi symport; however, the biochemical mechanism of NAD+ in this action is not clarified. We now propose that NAD+ acts indirectly by first being converted to cyclic ADP-ribose (cADPR), a potent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4bc03a679e144f3ca564fa964a4bd7
https://doi.org/10.1152/ajpcell.1995.268.3.c741
https://doi.org/10.1152/ajpcell.1995.268.3.c741
Publikováno v:
Journal of Biological Chemistry. 270:3216-3223
Transient fluxes of intracellular ionized calcium (Ca2+) from intracellular stores are integral components of regulatory signaling pathways operating in numerous biological regulations, including in early stages of egg fertilization. Therefore, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44a0042a9a7f8bf5c988c769df398e2
https://doi.org/10.1074/jbc.270.7.3216
https://doi.org/10.1074/jbc.270.7.3216
Autor:
R.T. Wang, Kelly W. Beers, Dianne K. Anestis, Derek W. Nicoll, Vonda J. Teets, Gary O. Rankin, Patrick I. Brown
Publikováno v:
Toxicology. 88:151-164
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is an established nephrotoxicant in male Fischer 344 rats at i.p. doses of ≥ 0.4 mmol/kg. Since gender differences often exist in the susceptibility to toxicants, the nephrotoxic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aa6fcad6f217b1a4cf9b9f0b87dd6b
https://doi.org/10.1016/0300-483x(94)90117-1
https://doi.org/10.1016/0300-483x(94)90117-1
Autor:
Kelly W. Beers, Gary O. Rankin
Publikováno v:
Toxicology. 79:139-148
The experimental agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is a nephrotoxicant in the Fischer 344 rat. NDPS induces nephrotoxicity via metabolic bioactivation to one or more metabolites. Both N-(3,5-dichlorophenyl)-2-hydroxysucc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6ac900ccf6417985f9847f404757c1
https://doi.org/10.1016/0300-483x(93)90127-e
https://doi.org/10.1016/0300-483x(93)90127-e
Autor:
Vonda J. Teets, Patrick I. Brown, Derek W. Nicoll, Dianne K. Anestis, Hsiencheng Shih, John L. Hubbard, Kelly W. Beers, Gary O. Rankin
Publikováno v:
Journal of Applied Toxicology. 12:211-216
Previous studies have demonstrated the importance of substitution at the 3- and 5-positions of the phenyl ring in N-phenylsuccinimides for the production of nephrotoxicants in this series of compounds. The purpose of this study was to determine if th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287932d3e0fe0ed0d30befb90f0ba26
https://doi.org/10.1002/jat.2550120311
https://doi.org/10.1002/jat.2550120311