β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats

Autor: Inar Alves de Castro, Mayara Lilian Paulino Miranda, Fábia de Oliveira Andrade, Raquel Santana da Cruz, Renato Heidor, Luis Fernando Barbisan, Maria do Socorro Nogueira, Fernando Salvador Moreno, Kelly Silva Furtado, Eduardo Purgatto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2019-10-06T16:34:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01 Among the primary neoplasias that affect the liver, hepatocellular carcinoma (HCC) is the most frequent and the third leading cause of death

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19dfb9022fa4886dbd4925dba98fd6b
https://doi.org/10.1016/j.cbi.2019.05.046

β-ionone modulates the expression of miRNAs and genes involved in the metastatic phenotype of microdissected persistent preneoplastic lesions in rats submitted to hepatocarcinogenesis

Autor: Fábia de Oliveira Andrade, Aline de Conti, Aline Henriques, Clarissa Scolastici, Kelly Silva Furtado, Adriana Campos, Mariana Papaléo Rosim, Fernando Salvador Moreno, Ernesto Vargas-Mendez, Robson Francisco Carvalho, Luis Fernando Barbisan

Publikováno v: Molecular Carcinogenesis. 56:184-196

MicroRNAs (miRNAs) are post-transcriptional gene expression regulators which expression is frequently altered in hepatocellular carcinoma (HCC). β-ionone (βI) is noted for its ability to inhibit persistent preneoplastic lesions (pPNLs) in liver rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c3361223a16cbbc6740c84a00327ddb
https://doi.org/10.1002/mc.22483

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

Autor: Frederick A. Beland, Maria Aderuza Horst, Paulo Eduardo Latorre Martins Tavares, Laura Helena Gasparini Fernandes, Fernando Salvador Moreno, Svitlana Shpyleva, Igor P. Pogribny, Marta Pogribna, Aline de Conti, Kelly Silva Furtado, Volodymyr Tryndyak, Juliana Festa Ortega, Renato Heidor

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oncotarget

Hepatocellular carcinoma (HCC), an aggressive and the fastest growing life-threatening cancer worldwide, is often diagnosed at intermediate or advanced stages of the disease, which substantially limits therapeutic approaches for its successful treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d209e920f46bc47057b64e5562eaf2a9

β-ionone modulates the expression of miRNAs and genes involved in the metastatic phenotype of microdissected persistent preneoplastic lesions in rats submitted to hepatocarcinogenesis

Autor: Kelly Silva, Furtado, Fábia, de Oliveira Andrade, Adriana, Campos, Mariana Papaléo, Rosim, Ernesto, Vargas-Mendez, Aline, Henriques, Aline, De Conti, Clarissa, Scolastici, Luis Fernando, Barbisan, Robson Francisco, Carvalho, Fernando Salvador, Moreno

Publikováno v: Molecular carcinogenesis. 56(1)

MicroRNAs (miRNAs) are post-transcriptional gene expression regulators which expression is frequently altered in hepatocellular carcinoma (HCC). β-ionone (βI) is noted for its ability to inhibit persistent preneoplastic lesions (pPNLs) in liver rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74d6825ee38f5df0638003d7b78893f5
https://pubmed.ncbi.nlm.nih.gov/27061051

β-ionone inhibits persistent preneoplastic lesions during the early promotion phase of rat hepatocarcinogenesis: TGF-α, NF-κB, and p53 as cellular targets

Autor: Clarissa Scolastici, Maria Aderuza Horst, Fernando Salvador Moreno, Aline de Conti, Renato Heidor, Thomas Prates Ong, Kelly Silva Furtado, Bruna Kempfer Bassoli, Eduardo Purgatto, Mônica Testoni Cardozo

Publikováno v: Nutrition and cancer. 66(2)

Dietary isoprenic derivatives such as β-ionone (βI) are a promising class of chemopreventive agents. In this study, cellular aspects of βI protective activities during early hepatocarcinogenesis were evaluated. Male Wistar rats were submitted to "

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae63c44719b1bb30479a7a69f921e005
https://pubmed.ncbi.nlm.nih.gov/24364727