Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei .

Autor: Alghamdi AH; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Munday JC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Campagnaro GD; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Gurvic D; Computational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom., Svensson F; IOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cambridge, United Kingdom., Okpara CE; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Kumar A; Chemistry Department, Georgia State University, Atlanta, United States., Quintana J; School of Life Sciences, University of Dundee, Dundee, United Kingdom., Martin Abril ME; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Milić P; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Watson L; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Paape D; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Settimo L; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Dimitriou A; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Wielinska J; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Smart G; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Anderson LF; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Woodley CM; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Kelly SPY; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Ibrahim HM; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Hulpia F; Laboratory for Medicinal Chemistry, University of Ghent, Ghent, Belgium., Al-Salabi MI; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Eze AA; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Sprenger T; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Teka IA; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Gudin S; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Weyand S; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Field M; School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic., Dardonville C; Instituto de Química Médica - CSIC, Madrid, Spain., Tidwell RR; Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States., Carrington M; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., O'Neill P; Department of Chemistry, University of Liverpool, Liverpool, United Kingdom., Boykin DW; Chemistry Department, Georgia State University, Atlanta, United States., Zachariae U; Computational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom., De Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: ELife [Elife] 2020 Aug 11; Vol. 9. Date of Electronic Publication: 2020 Aug 11.