Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Kelly S. E. Tanaka"'
1
Glycosidase-catalyzed hydrolysis of 2-deoxyglucopyranosyl pyridinium salts: effect of the 2-OH group on binding and catalysis
Autor: Francesco Lipari, Jiang Zhu, Xicai Huang, Kelly S. E. Tanaka, Andrew J. Bennet
Publikováno v: Canadian Journal of Chemistry. 78:577-582
Three 2-deoxy-α-D-glucopyranosyl pyridinium tetrafluoroborates were tested for their binding affinity to a range of α-glucosidases and α-mannosidases. The α-isoquinolinium salt (11) binds approximately 275-fold more tightly to yeast α-glucosidas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::171d909be49db8eda433ca110db3fff8
https://doi.org/10.1139/v00-061
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2
Aqueous Ethanolysis of Unstrained Sterically Congested Homoallylic Halides
Autor: Kelly S. E. Tanaka, Andrew J. Bennet, Xicai Huang
Publikováno v: Journal of the American Chemical Society. 120:1405-1409
The aqueous ethanolysis reactions of the adamantylideneadamantyl halides (2-Cl, 2-Br, and 2-I) exhibit Grunwald−Winstein sensitivity parameters (m) of 0.74 ± 0.06, 0.90 ± 0.01, and 0.88 ± 0.03 for the chloride, bromide, and iodide compounds, res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc82b6c9daada6e430b2434e368acec3
https://doi.org/10.1021/ja971909t
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4
Glucosidase-Catalyzed Hydrolysis of α-d-Glucopyranosyl Pyridinium Salts: Kinetic Evidence for Nucleophilic Involvement at the Glucosidation Transition State
Autor: and Kelly S. E. Tanaka, Andrew J. Bennet, Xicai Huang
Publikováno v: Journal of the American Chemical Society. 119:11147-11154
Kinetic isotope effects (KIEs) on the yeast α-glucosidase-catalyzed hydrolysis of two α-d-glucopyranosyl pyridinium salts were measured at 25 °C and pH = 6.8. The measured KIEs on kcat for the 2H-2, 13C-1, and 15N-1‘ labeled substrates α-d-gluc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9803ffbce88ed1bebcb1b09f3fb7ac97
https://doi.org/10.1021/ja963733l
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6
Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-Enzymatic Glycoside Hydrolysis and Transfer
Autor: Kelly S. E. Tanaka, Paul J. Berti
Publikováno v: ChemInform. 34
Publisher Summary This chapter attempts to provide a summary of the use of transition state (TS) analysis in understanding glycoside chemistry, as well as an overview of recent developments in the field. TS analysis is only one tool in any comprehens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54f5c82818e31b7bc4438f86d242b308
https://doi.org/10.1002/chin.200335251
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7
Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer
Autor: Paul J. Berti, Kelly S. E. Tanaka
Publisher Summary This chapter attempts to provide a summary of the use of transition state (TS) analysis in understanding glycoside chemistry, as well as an overview of recent developments in the field. TS analysis is only one tool in any comprehens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36194a1d2ad87300defadf9c5b7084a4
https://doi.org/10.1016/s0065-3160(02)37004-7
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8
Ricin A-chain inhibitors resembling the oxacarbenium ion transition state
Autor: Xiang-Yang Chen, Richard H. Furneaux, Vern L. Schramm, Kelly S. E. Tanaka, Peter C. Tyler, Yoshitaka Ichikawa
Publikováno v: Biochemistry. 40(23)
Ricin toxin A-chain (RTA) is expressed by the castor bean plant and is among the most potent mammalian toxins. Upon activation in the cytosol, RTA depurinates a single adenine from position 4324 of rat 28S ribosomal RNA, causing inactivation of ribos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1186c8ae1b8862b2b20fddc20097020b
https://pubmed.ncbi.nlm.nih.gov/11389598
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