Výsledky vyhledávání - "Kelly S Warmington"

RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats

Autor: Hua Z. Ke, Xiaodong Li, Mauricio Barrero, Michael S. Ominsky, Denise Dwyer, William S. Simonet, Frank Asuncion, James McCabe, Timothy J. Corbin, Paul J. Kostenuik, Zhaopo Geng, Marina Stolina, Kelly S Warmington, Hong-Lin Tan, Mario Grisanti

Publikováno v: Journal of Bone and Mineral Research. 23:672-682

Introduction: Ovariectomy (OVX) results in bone loss caused by increased bone resorption. RANKL is an essential mediator of bone resorption. We examined whether the RANKL inhibitor osteoprotegerin (OPG) would preserve bone volume, density, and streng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7c1205769881afcac0fdff739d866d
https://doi.org/10.1359/jbmr.080109

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Progressive increases in bone mass and bone strength in an ovariectomized rat model of osteoporosis after 26 weeks of treatment with a sclerostin antibody

Autor: William S. Simonet, Denise Dwyer, Xiaodong Li, Paul J. Kostenuik, Michael S. Ominsky, Michael Eschenberg, Marina Stolina, Chun-Ya Han, Hua Zhu Ke, Qing-Tian Niu, Kelly S Warmington, Franklin J. Asuncion, Mario Grisanti

Publikováno v: Endocrinology. 155(12)

The effects of up to 26 weeks of sclerostin antibody (Scl-Ab) treatment were investigated in ovariectomized (OVX) rats. Two months after surgery, 6-month-old osteopenic OVX rats were treated with vehicle or Scl-Ab (25 mg/kg, sc, one time per week) fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9595eb6770846b15c99ba605a969241
https://pubmed.ncbi.nlm.nih.gov/25259718

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Differential Expression and Cross-Regulatory Function of RANTES During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granulomatous Inflammation

Autor: Stephen W. Chensue, Kelly S. Warmington, Eric J. Allenspach, Bao Lu, Craig Gerard, Steven L. Kunkel, Nicholas W. Lukacs

Publikováno v: The Journal of Immunology. 163:165-173

The role of RANTES in Th1 and Th2 cell-mediated immune responses has been enigmatic. To approach this question, we analyzed RANTES expression and function in murine models of types 1 and 2 cell-mediated pulmonary granulomas elicited with Mycobacteriu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::610a9da7f9c66aa4af423a80a69323c4
https://doi.org/10.4049/jimmunol.163.1.165

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Expression and Participation of Eotaxin During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granuloma Formation

Autor: Jeffrey H. Ruth, Nicholas W. Lukacs, Kelly S. Warmington, Tim J. Polak, Marie Burdick, Steven L. Kunkel, Robert M. Strieter, Stephen W. Chensue

Publikováno v: The Journal of Immunology. 161:4276-4282

Eotaxin participation was analyzed during types 1 and 2 lung granuloma formation induced by embolizing Sepharose beads coupled to purified protein derivative (PPD) of Mycobacterium bovis or soluble Ags derived from Schistosoma mansoni eggs. Eotaxin w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f77a691f6dd3271c84279f2181543389
https://doi.org/10.4049/jimmunol.161.8.4276

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Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

Autor: Jianhua Gong, Roy A. Black, Qing Tian Niu, Hua Z. Ke, Kevin Graham, Efrain Pacheco, James Pretorius, Martine Roudier, Xiaodong Li, Kelly S Warmington, Joanne T. Hulme, Philip Babij, Bo Rin P. Yoon

Publikováno v: Arthritis and rheumatism. 65(3)

Objective Sclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known. The purpose of this study was to determine whether genetic loss or pharmacologic inhibition of sclerostin has an impact on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635525984c68184556a59da65ad51454
https://pubmed.ncbi.nlm.nih.gov/23233270

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Cross-regulatory role of interferon-gamma (IFN-γ), IL-4 and IL-10 in schistosome egg granuloma formation:in vivoregulation of Th activity and inflammation

Autor: S L Kunkel, Stephen W. Chensue, Jason R. Ruth, Kelly S. Warmington, Pamela M. Lincoln

Publikováno v: Clinical and Experimental Immunology. 98:395-400

SUMMARYThis study examined the relationship ofIL-4, IL-10 and IFN-γ with regard to the local granuloma (GR) and draining lymph node (LN) response to Schistosoma mansoni eggs. Synchronized GR were induced in naive and schistosome-infected mice at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24c1aac16fe89ab853fef7918cf373a
https://doi.org/10.1111/j.1365-2249.1994.tb05503.x

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Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats

Autor: Chris Paszty, Mario Grisanti, Mauricio Barrero, Paul J. Kostenuik, Xiaodong Li, Qing-Tian Niu, Kelly S Warmington, Franklin J. Asuncion, Hua Zhu Ke, Denise Dwyer, William S. Simonet, Marina Stolina, Michael S. Ominsky

Publikováno v: Endocrinology. 152(9)

Clinical studies have revealed a blunting of the bone anabolic effects of parathyroid hormone treatment in osteoporotic patients in the setting of pre- or cotreatment with the antiresorptive agent alendronate (ALN). Sclerostin monoclonal antibody (Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca210a6bce93e9631fff12d99d89e51
https://pubmed.ncbi.nlm.nih.gov/21733832

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Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin

Autor: Qing-Tian Niu, Denise Dwyer, Michael S. Ominsky, Hua Zhu Ke, Paul J. Kostenuik, Xiaodong Li, Zhaopo Geng, Kelly S Warmington, Frank Asuncion, Steven Adamu, W. Scott Simonet, Mario Grisanti, Hong-Lin Tan, Marina Stolina

Publikováno v: Bone. 45(4)

Orchiectomized (ORX) rats were used to examine the extent to which their increased bone resorption and decreased bone density might relate to increases in RANKL, an essential cytokine for bone resorption. Serum testosterone declined by >95% in ORX ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe703acdbfdb6b70397b4803208760c
https://pubmed.ncbi.nlm.nih.gov/19539794

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 24(4)

The development of bone-rebuilding anabolic agents for potential use in the treatment of bone loss conditions, such as osteoporosis, has been a long-standing goal. Genetic studies in humans and mice have shown that the secreted protein sclerostin is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933891e04b0d3ab19566c0b6238b9b4b
https://pubmed.ncbi.nlm.nih.gov/19335216

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