Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Kelly R. Monk"'
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin (Gphn)-null mice, where glycine receptors are depleted fr
Externí odkaz:
https://doaj.org/article/813713a6764845f1b744b58eaaf6d624
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1
Externí odkaz:
https://doaj.org/article/11212149181f416b8c3e590d274fb1a6
Autor:
Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, Demet Araç
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and si
Externí odkaz:
https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
Autor:
Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau, Judith P. Golden, David A. Lyons, Jonah R. Chan, Kelly R. Monk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.
Externí odkaz:
https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
Publikováno v:
Neural Development, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann
Externí odkaz:
https://doaj.org/article/bc035e7148144a60af312c87db988eed
Autor:
Nicholas E. Sanchez, Breanne L. Harty, Thomas O’Reilly-Pol, Sarah D. Ackerman, Amy L. Herbert, Melanie Holmgren, Stephen L. Johnson, Ryan S. Gray, Kelly R. Monk
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3415-3425 (2017)
As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology or through transgenic approaches, such as many nervous system defects, has also increased. Screening for these difficult-t
Externí odkaz:
https://doaj.org/article/915cc7e9a3d84911b8c33fd90127b6f0
Autor:
Albina Jablonka-Shariff, PhD, Johnny Chuieng-Yi Lu, MD, MS, Katherine Campbell, BA, Kelly R. Monk, PhD, Alison K. Snyder-Warwick, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 8, Iss 4S, Pp 132-133 (2020)
Externí odkaz:
https://doaj.org/article/f767bd1278e9440aafe9406c6d4b8c73
Autor:
Ines Liebscher, Julia Schön, Sarah C. Petersen, Liane Fischer, Nina Auerbach, Lilian Marie Demberg, Amit Mogha, Maxi Cöster, Kay-Uwe Simon, Sven Rothemund, Kelly R. Monk, Torsten Schöneberg
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2018-2026 (2014)
Adhesion G protein-coupled receptors (aGPCRs) comprise the second largest yet least studied class of the GPCR superfamily. aGPCRs are involved in many developmental processes and immune and synaptic functions, but the mode of their signal transductio
Externí odkaz:
https://doaj.org/article/3f3477fcd9df49e4bfc98d591c8d863e
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1342-1352 (2013)
Microglia are phagocytic cells that form the basis of the brain’s immune system. They derive from primitive macrophages that migrate into the brain during embryogenesis, but the genetic control of microglial development remains elusive. Starting wi
Externí odkaz:
https://doaj.org/article/1aebe8d7e96144da93ea3b645cd9db9c
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 135-145 (2013)
SUMMARY Mutations in SEC63 cause polycystic liver disease in humans. Sec63 is a member of the endoplasmic reticulum (ER) translocon machinery, although it is unclear how mutations in SEC63 lead to liver cyst formation in humans. Here, we report the i
Externí odkaz:
https://doaj.org/article/9b7c2faad14d41c79cd14966e4379f41