Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Kelly R. Monk"'
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin (Gphn)-null mice, where glycine receptors are depleted fr
Externí odkaz:
https://doaj.org/article/813713a6764845f1b744b58eaaf6d624
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1
Externí odkaz:
https://doaj.org/article/11212149181f416b8c3e590d274fb1a6
Autor:
Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, Demet Araç
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and si
Externí odkaz:
https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
Autor:
Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau, Judith P. Golden, David A. Lyons, Jonah R. Chan, Kelly R. Monk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.
Externí odkaz:
https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
Publikováno v:
Neural Development, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann
Externí odkaz:
https://doaj.org/article/bc035e7148144a60af312c87db988eed
Autor:
Nicholas E. Sanchez, Breanne L. Harty, Thomas O’Reilly-Pol, Sarah D. Ackerman, Amy L. Herbert, Melanie Holmgren, Stephen L. Johnson, Ryan S. Gray, Kelly R. Monk
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3415-3425 (2017)
As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology or through transgenic approaches, such as many nervous system defects, has also increased. Screening for these difficult-t
Externí odkaz:
https://doaj.org/article/915cc7e9a3d84911b8c33fd90127b6f0
Autor:
Albina Jablonka-Shariff, PhD, Johnny Chuieng-Yi Lu, MD, MS, Katherine Campbell, BA, Kelly R. Monk, PhD, Alison K. Snyder-Warwick, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 8, Iss 4S, Pp 132-133 (2020)
Externí odkaz:
https://doaj.org/article/f767bd1278e9440aafe9406c6d4b8c73
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J.M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
SARM1 is a central regulator of programmed axon death and is required to initiate axon self-destruction after traumatic and toxic insults to the nervous system. Abnormal activation of this axon degeneration pathway is increasingly recognized as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb1fe267175f2f740304601c4e3b108
https://doi.org/10.1101/2022.12.08.519209
https://doi.org/10.1101/2022.12.08.519209
Autor:
Stefanie Giera, Rong Luo, Yanqin Ying, Sarah D Ackerman, Sung-Jin Jeong, Hannah M Stoveken, Christopher J Folts, Christina A Welsh, Gregory G Tall, Beth Stevens, Kelly R Monk, Xianhua Piao
Publikováno v:
eLife, Vol 7 (2018)
In the central nervous system (CNS), myelin formation and repair are regulated by oligodendrocyte (OL) lineage cells, which sense and integrate signals from their environment, including from other glial cells and the extracellular matrix (ECM). The s
Externí odkaz:
https://doaj.org/article/df855cc93c824dc2a33053125a2dd7c0
Autor:
Jiakun Chen, Tobias Stork, Yunsik Kang, Amy Sheehan, Cameron Paton, Kelly R. Monk, Marc R. Freeman
SUMMARYAstrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapse-associated membrane specializations, but signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here we show theDro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa12e533cacdc52c4a4110e347abe16
https://doi.org/10.1101/2022.09.15.508188
https://doi.org/10.1101/2022.09.15.508188