Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Kelly R Bales"'
Autor:
Erica Dresselhaus, James M Duerr, Fabien Vincent, Emily K Sylvain, Mercedes Beyna, Lorraine F Lanyon, Erik LaChapelle, Martin Pettersson, Kelly R Bales, Gayathri Ramaswamy
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194661 (2018)
Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human apoE isoforms, with sporadic and late onset forms of Alzheimer's disease (AD) little is kn
Externí odkaz:
https://doaj.org/article/214aaa2673324b92bf01f2321f37451d
Autor:
Rebecca Craig-Schapiro, Max Kuhn, Chengjie Xiong, Eve H Pickering, Jingxia Liu, Thomas P Misko, Richard J Perrin, Kelly R Bales, Holly Soares, Anne M Fagan, David M Holtzman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18850 (2011)
Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ∼10-15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onse
Externí odkaz:
https://doaj.org/article/e976640c1c5a4ccea2c12642381fa6f5
Autor:
Jinbin Xu, Jianjun Sun, Richard J. Perrin, Robert H. Mach, Kelly R. Bales, John C. Morris, Tammie L. S. Benzinger, David M. Holtzman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1423-1434 (2019)
Abstract Objective Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative di
Externí odkaz:
https://doaj.org/article/32dc89490adf48ffbc48eb040d3f5e30
Autor:
Wencheng Liu, Vinodh Kurella, Li Liu, Dillon Kavanagh, Maneesha Paranjpe, Jerrah Holth, Charlotte Chung, Alex Powers, Xiao‐Qin Ren, Yanqun Shu, Allen Capili, Jay Hou, Bernardino Francesco Ghetti, Kelly R. Bales, Steven M. Paul, Todd Carter
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781775f837964c9b9968c79c8b65a321
https://doi.org/10.1002/alz.062878
https://doi.org/10.1002/alz.062878
Autor:
Wencheng Liu, Maneesha Paranjpe, Jerrah Holth, Blaise Clarke, Jeffery Thompson, Joe Clement, Elisabeth Knoll, Charlotte Chung, Adewale Adeluyi, Alex Powers, Vinodh Kurella, Dillon Kavanagh, Brian Ezell, Timothy Fiore, Kyle Grant, Jay Hou, Kelly R. Bales, Steven M. Paul, Todd Carter
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b87f0006149b9d3bce8f02e594fc040
https://doi.org/10.1002/alz.062924
https://doi.org/10.1002/alz.062924
Autor:
Wencheng Liu, Jerrah Holth, Maneesha Paranjpe, Xiao‐Qin Ren, Yanqun Shu, Giridhar Murlidharan, Charlotte Chung, Alex Powers, Emalee Peterson, Abigail Ecker, Usman Hameedi, Kyle Grant, Vinodh Kurella, Dillon Kavanagh, Omar Khwaja, Jay Hou, Steven M. Paul, Kelly R. Bales, Todd Carter
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8030993a1110767211d304cd8d6a007
https://doi.org/10.1002/alz.053341
https://doi.org/10.1002/alz.053341
Autor:
Kelly R. Bales, Jianjun Sun, Tammie L.S. Benzinger, John C. Morris, Jinbin Xu, David M. Holtzman, Richard J. Perrin, Robert H. Mach
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1423-1434 (2019)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e75ce021a3df9a92df2425142dc65af
https://doi.org/10.1002/acn3.50837
https://doi.org/10.1002/acn3.50837
Autor:
Anne M. Fagan, Melanie Watson, Maia Parsadanian, Kelly R. Bales, Steven M. Paul, David M. Holtzman
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 3, Pp 305-318 (2002)
The ϵ4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease (AD), perhaps through effects on amyloid-β (Aβ) metabolism. Detailed analyses of various Aβ parameters in aging APPV717F+/− transgenic mice expressing mouse apoE,
Externí odkaz:
https://doaj.org/article/a5805601b06e49d0ad2c9bfea6d70043
Autor:
Jean-Cosme Dodart, Chantal Mathis, Josep Saura, Kelly R. Bales, Steven M. Paul, Arielle Ungerer
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 2, Pp 71-85 (2000)
Histological analyses were performed on the brains of APPV717F transgenic (Tg)mice previously studied in a battery of behavioral tests. We describe here the regional and age-dependent deposition of amyloid in both heterozygous and homozygous Tg mice.
Externí odkaz:
https://doaj.org/article/e0c3a31146564671842d8f1bdd09d3eb
Autor:
Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck
Publikováno v:
Journal of Medicinal Chemistry. 61:4476-4504
A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16220e824d55c04d1dd3342582ab393
https://doi.org/10.1021/acs.jmedchem.8b00246
https://doi.org/10.1021/acs.jmedchem.8b00246