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High- and low-dose oral immunotherapy similarly suppress pro-allergic cytokines and basophil activation in young children

Autor: Ping Ye, Quefeng Li, Yutong Liu, Edwin H. Kim, Brian P. Vickery, Michael D. Kulis, A.W. Burks, Rishu Guo, Huamei Zhang, Xiaohong Yue, Kelly Orgel

Publikováno v: Clinical & Experimental Allergy. 49:180-189

Background Mechanisms underlying oral immunotherapy (OIT) are unclear and the effects on immune cells at varying maintenance doses are unknown. Objective We aimed to determine the immunologic changes caused by peanut OIT in preschool aged children an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f8164c3c8566ff7686977b3e63e452
https://doi.org/10.1111/cea.13256

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Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy

Autor: Yusuke Nakamura, A. Wesley Burks, Tu H Mai, Kazuma Kiyotani, Kelly Orgel, Seiya Imoto, Poh Yin Yew, Rui Yamaguchi, Mike Kulis, Satoru Miyano

Publikováno v: Journal of Human Genetics. 63:239-248

B-cell receptors (BCRs) play a critical role in adaptive immunity as they generate highly diverse immunoglobulin repertoires to recognize a wide variety of antigens. To better understand immune responses, it is critically important to establish a qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31513db710943cc08ee9b5af31257547
https://doi.org/10.1038/s10038-017-0364-0

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Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

Autor: Rachael Rigby, Jacquelyn Carr, Kelly Orgel, Stephanie L. King, Christopher M. Dekaney, P. Kay Lund

Publikováno v: Gut Microbes. 7:414-423

Doxorubicin (DOXO) induces significant, but transient, increases in apoptosis in the stem cell zone of the jejunum, followed by mucosal damage involving a decrease in crypt proliferation, crypt number, and villus height. The gastrointestinal tract is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d53673add4839b5b74dc4f73d16791
https://doi.org/10.1080/19490976.2016.1215806

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Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness

Autor: A.W. Burks, Scott H. Sicherer, Brian P. Vickery, D. Stablein, Hugh A. Sampson, Stacie M. Jones, Benjamin L. Wright, Peter Dawson, Kelly Orgel, Robert A. Wood, Donald Y.M. Leung, Robert Lindblad, Mike Kulis, Alice K. Henning

Publikováno v: Allergy. 71:1552-1560

Background In a previously reported CoFAR study, 55 subjects with egg allergy underwent randomized, placebo-controlled egg oral immunotherapy (eOIT). Active treatment induced desensitization in most and sustained unresponsiveness (SU) in a smaller su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7aeeb134a9e215924178d6a7ea4ffc
https://doi.org/10.1111/all.12895

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A Mouse Model of Peanut Allergy Induced by Sensitization Through the Gastrointestinal Tract

Autor: Kelly Orgel, Michael D. Kulis

Publikováno v: Methods in Molecular Biology ISBN: 9781493978953

Animal models of disease enable the study of the pathology, biomarkers, and treatments for the disease being studied. These models become particularly useful in the study of diseases, such as peanut allergy, that currently have no FDA-approved therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaf85fe4a10252c7039f290325389c8f
https://doi.org/10.1007/978-1-4939-7896-0_4

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Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy

Autor: Darla R. Miller, Martin T. Ferris, Michael D. Kulis, Johanna Smeekens, Rishu Guo, Fernando Pardo-Manuel de Villena, A. Wesley Burks, Ping Ye, Lauren Fotsch, Kelly Orgel

Publikováno v: J Allergy Clin Immunol

Background Improved animal models are needed to understand the genetic and environmental factors that contribute to food allergy. Objective We sought to assess food allergy phenotypes in a genetically diverse collection of mice. Methods We selected 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05864561561637777cdeb15f5867d29
https://doi.org/10.1016/j.jaci.2018.10.009

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