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pro vyhledávání: '"Kelly N. Steele"'
Autor:
Fiona H. Marshall, Juan Carlos Mobarec, Susan H. Brown, James C. Errey, Stephen P. Andrews, Jonathan S. Mason, Malcolm Peter Weir, Kelly N. Steele, Ali Jazayeri, Robert M. Cooke, A. O'Brien, Charlotte Fieldhouse, Iryna Teobald, Alastair J. H. Brown, Brown Giles Albert, Bortolato Andrea, John A. Christopher, Asma H. Baig, Chris de Graaf, Stacey M. Southall, Steve P. Watson, Krzysztof Okrasa, Miles Congreve
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126611
A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2bdabc56cf80d85af953bc302e66f6
https://doi.org/10.1016/j.bmcl.2019.08.015
https://doi.org/10.1016/j.bmcl.2019.08.015
