Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kelly N Owens"'
Autor:
Dale W Hailey, Brock Roberts, Kelly N Owens, Andrew K Stewart, Tor Linbo, Remy Pujol, Seth L Alper, Edwin W Rubel, David W Raible
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002971 (2012)
Mechanosensory hair cell death is a leading cause of hearing and balance disorders in the human population. Hair cells are remarkably sensitive to environmental insults such as excessive noise and exposure to some otherwise therapeutic drugs. However
Externí odkaz:
https://doaj.org/article/c817d9bc742546ae8d4b85761ce705e9
Autor:
Kelly N Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B Coffin, Anna J Knisely, Julian A Simon, Edwin W Rubel, David W Raible
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e1000020 (2008)
Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide. While normal aging is the single greatest contributor, exposure to environmental toxins an
Externí odkaz:
https://doaj.org/article/4e47d174a9de48dd980ebcc8c300aaa8
Autor:
Tamara M. Stawicki, Liana Hernandez, Robert Esterberg, Tor Linbo, Kelly N. Owens, Arish N. Shah, Nihal Thapa, Brock Roberts, Cecilia B. Moens, Edwin W. Rubel, David W. Raible
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2225-2235 (2016)
Hair cells possess a single primary cilium, called the kinocilium, early in development. While the kinocilium is lost in auditory hair cells of most species it is maintained in vestibular hair cells. It has generally been believed that the primary ro
Externí odkaz:
https://doaj.org/article/b1ded0c795714326a4abdfe48d02ce62
The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function
Autor:
Tamara M. Stawicki, Kelly N. Owens, Tor Linbo, Katherine E. Reinhart, Edwin W. Rubel, David W. Raible
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 847-856 (2014)
Control of the extracellular environment of inner ear hair cells by ionic transporters is crucial for hair cell function. In addition to inner ear hair cells, aquatic vertebrates have hair cells on the surface of their body in the lateral line system
Externí odkaz:
https://doaj.org/article/7e2a24f40b6b460795a785482b196dcf
Autor:
Vincent E. Groppi, Kelly N. Owens, R. Jason Herr, Xinchao Chen, Edwin W. Rubel, Julian A. Simon, Graham Johnson, Qin Jiang, David W. Raible, Sarwat Chowdhury
Publikováno v:
Journal of medicinal chemistry. 61(1)
Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells—a robust model for mammalian auditory and vestibular hair cells— we identified a urea-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a39b6646f80bd8e165518d45bfcbb
https://pubmed.ncbi.nlm.nih.gov/28992413
https://pubmed.ncbi.nlm.nih.gov/28992413
Autor:
Tor Linbo, David W. Raible, Katherine E. Reinhart, Kelly N. Owens, Edwin W. Rubel, Tamara M. Stawicki
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 847-856 (2014)
Disease Models & Mechanisms
Disease Models & Mechanisms
Control of the extracellular environment of inner ear hair cells by ionic transporters is crucial for hair cell function. In addition to inner ear hair cells, aquatic vertebrates have hair cells on the surface of their body in the lateral line system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f35e614c225c71bf5b4ee81a155cf7
https://doi.org/10.1242/dmm.016576
https://doi.org/10.1242/dmm.016576
Autor:
Brock Roberts, Liana Hernandez, Robert Esterberg, David W. Raible, Arish N Shah, Tor Linbo, Tamara M. Stawicki, Nihal Thapa, Kelly N. Owens, Edwin W. Rubel, Cecilia B. Moens
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2225-2235 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2225-2235 (2016)
Hair cells possess a single primary cilium, called the kinocilium, early in development. While the kinocilium is lost in auditory hair cells of most species it is maintained in vestibular hair cells. It has generally been believed that the primary ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a38468249a1833e23a93d3b79fe89ce
https://pubmed.ncbi.nlm.nih.gov/27207957
https://pubmed.ncbi.nlm.nih.gov/27207957
Autor:
Keri O. Bennett, Lisa S. Hong, David W. Raible, Edwin W. Rubel, Allison B. Coffin, Kelly N. Owens
Publikováno v:
Hearing Research. 253:32-41
We report a series of experiments investigating the kinetics of hair cell loss in lateral line neuromasts of zebrafish larvae following exposure to aminoglycoside antibiotics. Comparisons of the rate of hair cell loss and the differential effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96732dbb149fb3c652570fbe72c5cc81
https://doi.org/10.1016/j.heares.2009.03.001
https://doi.org/10.1016/j.heares.2009.03.001
Publikováno v:
Hearing Research. 253:42-51
Aminoglycoside antibiotics cause death of sensory hair cells. Research over the past decade has identified several key players in the intracellular cascade. However, the role of the extracellular environment in aminoglycoside ototoxicity has received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf69b9935c1f1affde1187f19a450a96
https://doi.org/10.1016/j.heares.2009.03.004
https://doi.org/10.1016/j.heares.2009.03.004
Publikováno v:
International Journal of Epidemiology. 31:53-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f50fffd7a189e3bda7b4ba274788911
https://doi.org/10.1093/ije/31.1.53
https://doi.org/10.1093/ije/31.1.53