Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kelly McKevitt"'
Autor:
Derya Unutmaz, Lina Kozhaya, Jacob L. McCauley, Kelly McKevitt, Ivana M. Djuretic, Maria T. Abreu, Mark S. Sundrud, Radha Ramesh, Maria A. Quintero, Thaddeus J. Carlson
Publikováno v:
The Journal of Experimental Medicine
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids
Autor:
Amanda P. Beck, Alexander Rodriguez-Palacios, Erumbi S. Rangarajan, Gustavo J. Martinez, Mei Lan Chen, Amber Delmas, Angelos Oikonomopoulos, Daniel W. Hommes, Sang Yong Kim, Robin G. Lorenz, Wei Cao, Mark S. Sundrud, Precious Lacey, Amy Sun, Cody B. Jackson, Maria T. Abreu, Gogce Crynen, Fabio Cominelli, Kelly McKevitt, Sergei B. Koralov, Hisako Kayama, Kiyoshi Takeda, Tina Izard
Publikováno v:
Immunity. 47:1182-1196.e10
Summary CD4 + T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4 + T effector (Teff) cells upregulated the xenobiotic transporter,
Autor:
Mark S Sundrud, Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Kelly McKevitt, Erumbi S. Rangarajan, Amanda P. Beck, Angelos Oikonomopoulos, Precious N. Lacey, Gustavo J Martinez, Tina Izard, Robin G Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T Abreu, Daniel W. Hommes, Sergei B Koralov, Kiyoshi Takeda
Publikováno v:
The Journal of Immunology. 198:65.14-65.14
Intestinal CD4+ T helper (TH) cells are subject to extensive regulation by microbiota. By contrast, it is not known whether or how TH cells interface with other, host-derived intestinal metabolites. Here we show that bile acids directly regulate muco
Autor:
Mark Sundrud, Radha Ramesh, Lina Kozhaya, Kelly McKevitt, Ivana Djuretic, Thaddeus Carlson, Maria Quintero, Jacob McCauley, Maria Abreu
Publikováno v:
The Journal of Immunology. 192:185.26-185.26
Th17 cells are generally regarded as key effectors of autoimmune disease. However, not all Th17 cells are pro-inflammatory. Furthermore, the defining features of "pathogenic" Th17 cells in humans are unknown. We have found that pro-inflammatory human