AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid.

Autor: Chen DF; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA., Roe LT; Department of Chemistry, University of California, Berkeley, CA., Li Y; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA., Borges AL; Arcadia Science, Berkeley, CA, USA., Zhang JY; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA., Babbar P; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Maji S; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Stevens MGV; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA., Diolaiti ME; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Smith DH; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Ashworth A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA., Stroud RM; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Kelly MJS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA., Bondy-Denomy J; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA.; Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA.; Innovative Genomics Institute, Berkeley, CA, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.; Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 26. Date of Electronic Publication: 2024 Aug 26.

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening.

Autor: Ortiz G; Department of Cellular and Molecular Pharmacology, University of California San Francisco San Francisco CA 94158 USA danica.fujimori@ucsf.edu., Longbotham JE; Department of Cellular and Molecular Pharmacology, University of California San Francisco San Francisco CA 94158 USA danica.fujimori@ucsf.edu., Qin SL; Department of Cellular and Molecular Pharmacology, University of California San Francisco San Francisco CA 94158 USA danica.fujimori@ucsf.edu., Zhang MY; Department of Cellular and Molecular Pharmacology, University of California San Francisco San Francisco CA 94158 USA danica.fujimori@ucsf.edu., Lee GM; Small Molecule Discovery Center (SMDC), University of California San Francisco San Francisco CA 94158 USA.; Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco CA 94158 USA., Neitz RJ; Small Molecule Discovery Center (SMDC), University of California San Francisco San Francisco CA 94158 USA.; Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco CA 94158 USA., Kelly MJS; Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco CA 94158 USA., Arkin MR; Small Molecule Discovery Center (SMDC), University of California San Francisco San Francisco CA 94158 USA.; Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco CA 94158 USA., Fujimori DG; Department of Cellular and Molecular Pharmacology, University of California San Francisco San Francisco CA 94158 USA danica.fujimori@ucsf.edu.; Department of Pharmaceutical Chemistry, University of California San Francisco San Francisco CA 94158 USA.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2023 Dec 18; Vol. 5 (3), pp. 209-215. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations.

Autor: Ugur FS; Chemistry and Chemical Biology Graduate Program, 600 16th St., San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, 600 16th St., San Francisco, CA 94158, USA., Kelly MJS; Department of Pharmaceutical Chemistry, 600 16th St., San Francisco, CA 94158, USA., Fujimori DG; Department of Pharmaceutical Chemistry, 600 16th St., San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, 600 16th St., San Francisco, CA 94158, USA; Quantitative Biosciences Institute, University of California, San Francisco, 600 16th St., San Francisco, CA 94158, USA. Electronic address: danica.fujimori@ucsf.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2023 Jan 30; Vol. 435 (2), pp. 167913. Date of Electronic Publication: 2022 Dec 07.

Systems-level effects of allosteric perturbations to a model molecular switch.

Autor: Perica T; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Mathy CJP; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA., Xu J; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; The J. David Gladstone Institutes, San Francisco, CA, USA., Jang GΜ; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; The J. David Gladstone Institutes, San Francisco, CA, USA., Zhang Y; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA., Kaake R; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; The J. David Gladstone Institutes, San Francisco, CA, USA., Ollikainen N; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, USA., Braberg H; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; The J. David Gladstone Institutes, San Francisco, CA, USA., Swaney DL; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; The J. David Gladstone Institutes, San Francisco, CA, USA., Lambright DG; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA., Kelly MJS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Krogan NJ; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; The J. David Gladstone Institutes, San Francisco, CA, USA. nevan.krogan@ucsf.edu., Kortemme T; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. kortemme@cgl.ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. kortemme@cgl.ucsf.edu.; The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA. kortemme@cgl.ucsf.edu.; Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, USA. kortemme@cgl.ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. kortemme@cgl.ucsf.edu.

Publikováno v: Nature [Nature] 2021 Nov; Vol. 599 (7883), pp. 152-157. Date of Electronic Publication: 2021 Oct 13.

Disruption of the nascent polypeptide-associated complex leads to reduced polyglutamine aggregation and toxicity.

Autor: Dublin-Ryan, Leeran B.¹ (AUTHOR), Bhadra, Ankan K.¹ (AUTHOR), True, Heather L.¹ (AUTHOR) heather.true@wustl.edu

Publikováno v: PLoS ONE. 8/15/2024, Vol. 19 Issue 8, p1-18. 18p.