Výsledky vyhledávání - "Kelly M. Zullo"

Supplementary Figure 1 from Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Autor: Owen A. O'Connor, Daruka Mahadevan, Jimmy Duong, Serge Cremers, Renu Nandakumar, Yinghui Mao, Jennifer E. Amengual, Luigi Scotto, Michael Mangone, Xavier Jirau-Serrano, Laurence Cooke, Yige Guo, Kelly M. Zullo

Supplementary Figure 1. 0.75 nM of PDX in combination with 100 nM of alisertib was obsereved in a schedule dependent manner to evaluate drug:drug interactions. Simultaneous incubation of drugs is depicted as (I), while schedule (drug A before Drug B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35871117c115cf44c73a9ea3c9d1e63b
https://doi.org/10.1158/1078-0432.22457022

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Data from Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Purpose: Aurora A kinase (AAK) is expressed exclusively during mitosis, and plays a critical role in centrosome duplication and spindle formation. Alisertib is a highly selective AAK inhibitor that has demonstrated marked clinical activity of alisert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518812210463516dac33e39bd5882431
https://doi.org/10.1158/1078-0432.c.6523485.v1

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Data from Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma

Autor: Owen A. O'Connor, Susan E. Bates, Ronald Realubit, Charles Karan, Changchun Deng, Jennifer E. Amengual, Govind Bhagat, Yuan Zhang, Ying Wei, Tiffany Thomas, Serge Cremers, Kenneth P. Olive, Stephen A. Sastra, Carmine F. Palermo, Luigi Scotto, Kelly M. Zullo, Xavier Jirau-Serrano, Salvia Jain

Purpose: T-cell lymphomas (TCL) are aggressive diseases, which carry a poor prognosis. The emergence of new drugs for TCL has created a need to survey these agents in a rapid and reproducible fashion, to prioritize combinations which should be priori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd2dfddf7581dd54f3a7709c025e733
https://doi.org/10.1158/1078-0432.c.6524241.v1

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Data from NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation

Autor: James L. Riley, Frederic D. Bushman, Mariusz A. Wasik, Amanda Watkins, Sarah Javaid, Kelly M. Zullo, David M. Walter, John W. Tobias, Hong Y. Wang, Qian Zhang, Hong Kong, Fang Wei, John K. Everett, Damian Maseda, David L. Cookmeyer, Jan M. Pawlicki

Fusion genes including NPM–ALK can promote T-cell transformation, but the signals required to drive a healthy T cell to become malignant remain undefined. In this study, we introduce NPM–ALK into primary human T cells and demonstrate induction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20f6714951d33f88fe6b2fb26cd1da33
https://doi.org/10.1158/0008-5472.c.6513093.v1

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Supplementary Figures 1-2, Supplementary Table 1 from Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma

Supplementary Figures 1-2, Supplementary Table 1. Supplementary Figure 1: Highthroughput Matrix For H9 and HH. Highthroughput screen was used to determine the synergistic interaction in vitro in H9 and HH T-cell lines. (A) Depicts the observed percen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f762b80976191778cfffa83497553ca
https://doi.org/10.1158/1078-0432.22459545.v1

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Video 1 from Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Video 1. Using a live cell imaging system, H9 cell line was treated from 0- 72 hours with (A) Untreated Control (B) 2 nM Romidepsin (C) 100 nM Alisertib (D) 2nM Romidepsin and 100 nM Alisertib. Videos demonstrate live cell imaging of H9 during the sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ceadd3e16ec423b7f885c274b0e0ba
https://doi.org/10.1158/1078-0432.22457019.v1

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Supplementary Data from NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation

Supplemental Figures and Tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d89386f5b63da356d8b6f0553374478
https://doi.org/10.1158/0008-5472.22428660.v1

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