Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kelly M. Treonze"'
The fibrinogen cleavage product A -Val360, a specific marker of neutrophil elastase activity in vivo
Autor:
Qian Si, Richard I Carter, Ali Ahmad, Richard A. Mumford, Asger Dirksen, Kelly M. Treonze, Robert A. Stockley, Paul E. Finke, P. Davies, John L. Humes, Eeva Piitulainen
Publikováno v:
Thorax. 66:686-691
Background Alpha-1-antitrypsin (A1AT) deficiency is the only recognised genetic risk factor for chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. Since A1AT is the major inhibitor of neutrophil elasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4094f5794c3403ea4759a9717892db
https://doi.org/10.1136/thx.2010.154690
https://doi.org/10.1136/thx.2010.154690
Autor:
Kelly M. Treonze, Russell B. Lingham, Richard A. Mumford, Kenneth Alves, Benito Munoz, Weichao Chen, Joyce P. James, Jasmine Zunic, Nicholas D. Smith, Thomas S. Reger, Bowei Wang, Michael F. Gardner, Nicholas Stock, Mitchell D. Green, Qian Si
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1173-1176
A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418233da95288470cb2c8fbb4c8b2413
https://doi.org/10.1016/j.bmcl.2009.12.009
https://doi.org/10.1016/j.bmcl.2009.12.009
Autor:
Salony Maniar, Russell B. Lingham, Benito Munoz, Michael F. Gardner, Kenneth Alves, Alec D. Lebsack, Shankar Venkatraman, Joyce K. James, Qian Si, Bowei Wang, Richard A. Mumford, Nicholas Stock, Kelly M. Treonze, Jasmine Zunic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5803-5806
A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline 4-position with cyclic amines was evaluated as VLA-4 antagonists. The ring size and presence or absence of fluorine affected potency and receptor occup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab26f3bff50ff8e8ec08ba0ecbfbcc77
https://doi.org/10.1016/j.bmcl.2009.07.111
https://doi.org/10.1016/j.bmcl.2009.07.111
Autor:
Kenneth Alves, Thomas S. Reger, Kelly M. Treonze, Susan Nicolich, Patricia Kellerhouse, Salony Maniar, Paul A. Fischer, Donald W. Nicholson, Jasmine Zunic, Russell B. Lingham, Donald F. Hora, Peppi Prasit, Nicholas D. Smith, Richard A. Mumford, Keith Judd, Alison A. Kulick, Donald Thompson, Qian Si, William K. Hagmann, Benito Munoz, Ken Vakerich
Publikováno v:
Veterinary Immunology and Immunopathology. 130:79-87
The purpose of this study was to characterize the alpha(4)beta(1) receptor (CD49d/CD29, very late antigen-4, VLA-4) on circulating equine leukocytes and to evaluate the intrinsic potency of an alpha(4)beta(1) receptor antagonist (Compound B) in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2519d0b2f73ce500e2d2ca3d32c8e1
https://doi.org/10.1016/j.vetimm.2009.01.011
https://doi.org/10.1016/j.vetimm.2009.01.011
Autor:
Gerard R. Kieczykowski, Carrie P. Jones, Ping Liu, Junying Wang, Conrad E. Raab, Qian Si, Xinchun Tong, Thomas J. Lanza, Anne Schuelke, Kelly M. Treonze, Richard A. Mumford, Salony Manior, Stella H. Vincent, James V. Pivnichny, Gloria C. Koo, James P. Jewell, William K. Hagmann, Regina W. Wang, Philip Davies, Linus S. Lin, Malcolm MacCoss
Publikováno v:
Journal of Medicinal Chemistry. 52:3449-3452
Extremely potent very late antigen-4 (VLA-4) antagonists with picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an amino substituent on the proline fragment of the initial lead structure. This level of poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a2b44376091abb5e0b00c51b9e55a39
https://doi.org/10.1021/jm900257b
https://doi.org/10.1021/jm900257b
Publikováno v:
D46. CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DIAGNOSIS AND EVALUATION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f214cd03a7c125dc03d5f347bc353a5
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5966
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5966
Autor:
Qian Si, David C. Dale, Andrew A. Aprikyan, Nara A. Markosyan, Vahagn Makaryan, Richard A. Mumford, Paul E. Finke, Salony Maniar, Kelly M. Treonze
Publikováno v:
Blood. 112:3561-3561
Severe congenital neutropenia (SCN) is a rare autosomal dominant or recessive disorder with a characteristic “maturation arrest” at the promyelocytic stage of differentiation in the bone marrow and extremely low level of neutrophils in peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee16e0b01edfd9f4c8d45f01e5f568c2
https://doi.org/10.1182/blood.v112.11.3561.3561
https://doi.org/10.1182/blood.v112.11.3561.3561
Autor:
Nara A. Markosyan, Ruben Abagyan, Andrew A. Aprikyan, Paul E. Finke, Qian Si, Richard A. Mumford, Vahagn Makaryan, David C. Dale, Maxim Totrov, Kelly M. Treonze
Publikováno v:
Blood. 110:664-664
Severe congenital neutropenia (SCN) is a rare hematopoietic disease characterized by maturation arrest at the promyelocytes, recurring severe infections, and evolution to leukemia. Heterozygous mutations in either the neutrophil elastase (NE, ELA2) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d778bf388991d26c19114a4e39436e71
https://doi.org/10.1182/blood.v110.11.664.664
https://doi.org/10.1182/blood.v110.11.664.664