Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration

Autor: Marie Locard-Paulet, Claus Jørgensen, John Sinclair, Jonathan D. Worboys, Antoinette van Weverwijk, Kelly M McMahon, Yinyin Yuan, Lindsay Lim, Clare M. Isacke, Giulia Veluscek

Publikováno v: Science signaling. 9(414)

The exit of metastasizing tumor cells from the vasculature, extravasation, is regulated by their dynamic interactions with the endothelial cells that line the internal surface of vessels. To elucidate signals controlling tumor cell adhesion to the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d17d1e2bf4a038584e2abb277a4c83
https://pubmed.ncbi.nlm.nih.gov/26861043

Reproducible automated phosphopeptide enrichment using magnetic TiO2 and Ti-IMAC

Autor: John Sinclair, Robert Gourlay, Christopher J. Tape, Douglas J. Lamont, Jonathan D. Worboys, Douglas A. Lauffenburger, Claus Jørgensen, Matthias Trost, Kelly M McMahon, Janis Vogt

Publikováno v: Analytical Chemistry

Reproducible, comprehensive phosphopeptide enrichment is essential for studying phosphorylation-regulated processes. Here, we describe the application of hyper-porous magnetic TiO2 and Ti-IMAC microspheres for uniform automated phosphopeptide enrichm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efedd41b4717d0bf4ad5bb1a96428311
https://pubmed.ncbi.nlm.nih.gov/25233145

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Autor: Christopher J. Tape, Stephanie Ling, Maria Dimitriadi, Kelly M. McMahon, Jonathan D. Worboys, Hui Sun Leong, Ida C. Norrie, Crispin J. Miller, George Poulogiannis, Douglas A. Lauffenburger, Claus Jørgensen

Publikováno v: Cell
Tape, C J, Ling, S, Dimitriadi, M, McMahon, K M, Worboys, J D, Leong, H S, Norrie, I C, Miller, C J, Poulogiannis, G, Lauffenburger, D A & Jørgensen, C 2016, ' Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation ', Cell, vol. 165, no. 7, pp. 910–920 . https://doi.org/10.1016/j.cell.2016.05.079
Tape, C J, Ling, S, Dimitriadi, M, McMahon, K M, Worboys, J, Leong, H S, Norrie, I, Miller, C, Poulogiannis, G, Lauffenburger, D A & Jorgensen, C 2016, ' Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation ', Cell, vol. 165, no. 4, pp. 910-920 . https://doi.org/10.1016/j.cell.2016.03.029
Elsevier

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS[superscript G12D]) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1afaeedf7728a2b967fdfb5b18b1f8b
http://europepmc.org/articles/PMC5628167

Abstract 4571: A comparison of proteins and their expression levels within different regions of multi-cellular spheroids (MCTS)

Autor: Chris W. Sutton, Roger M. Phillips, Sham Naal, Kelly M. McMahon

Publikováno v: Cancer Research. 70:4571-4571

Introduction Hypoxia is a well established target for anticancer therapy. Within the tumor microenvironment, hypoxia does not reside alone; instead it exists in combination with multiple other physiological/biochemical changes. The occurrence of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f002067e70ce9c7c4cd8388eca2c87c5
https://doi.org/10.1158/1538-7445.am10-4571