Výsledky vyhledávání - "Kelly M. Makin"

In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone

Autor: Kelly M. Makin, Tracy L. Twinem, Robert D. Leunk, Siddhartha Roychoudhury, Ming Chu Hsu

Publikováno v: Microbial Drug Resistance

Selection of resistant strains in Streptococcus pneumoniae was studied in vitro with nemonoxacin, a novel nonfluorinated quinolone (NFQ), in comparison with quinolone benchmarks, ciprofloxacin, garenoxacin, and gatifloxacin. In stepwise resistance se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9b51078fedf6b41f3c800b02930fbb
http://europepmc.org/articles/PMC5073217

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Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones

Autor: Min Li, Kelly M. Makin, David H. Ellis, Erica Marie Kincaid, Allison A. Kreiner, Paul J. Renick, Benoit Ledoussal, Cynthia D. Wallace, Timothy W. Morris, David R. Macinga, Kirk J. Rupnik

Publikováno v: Antimicrobial Agents and Chemotherapy. 47:2526-2537

We have characterized an early series of 5,6-bridged dioxinoquinolones which behaved strikingly different from typical quinolones. The 5,6-bridged dioxinoquinolones inhibited Escherichia coli DNA gyrase supercoiling activity but, unlike typical quino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2b940a28c88615b655afd9c567acfb
https://doi.org/10.1128/aac.47.8.2526-2537.2003

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Quinolone Resistance in Staphylococci: Activities of New Nonfluorinated Quinolones against Molecular Targets in Whole Cells and Clinical Isolates

Autor: Kelly M. Makin, Paula M. Koenigs, Carl E. Catrenich, Helana D. McKeever, Benoit Ledoussal, Siddhartha Roychoudhury, Eric J. McIntosh

Publikováno v: Antimicrobial Agents and Chemotherapy. 45:1115-1120

The activity of three new, 8-methoxy-nonfluorinated quinolones (NFQs) against multiple-drug-resistant staphylococci was investigated. First, using Staphylococcus aureus strains containing point mutations in the serine 84–80 hot spots of the target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1cd6132757a371ec7d7be4e870e5ca
https://doi.org/10.1128/aac.45.4.1115-1120.2001

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Development and use of a high-throughput bacterial DNA gyrase assay to identify mammalian topoisomerase II inhibitors with whole-cell anticancer activity

Autor: Sandra Nelson, Tracy L. Twinem, David T. Stanton, Carl E. Catrenich, Kelly M. Makin, Siddhartha Roychoudhury

Publikováno v: Journal of biomolecular screening. 8(2)

A high-throughput screen (HTS) was developed and used to identify inhibitors of bacterial DNA gyrase. Among the validated hits were 53 compounds that also inhibited mammalian topoisomerase II with IC(50) values of12.5 micro g/mL for 51 of them. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac425abae76221d7afb84e4413e0ff5d
https://pubmed.ncbi.nlm.nih.gov/12844436

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Staphylococcus aureus Mutants Isolated via Exposure to Nonfluorinated Quinolones: Detection of Known and Unique Mutations

Autor: Carl E. Catrenich, Timothy W. Morris, Tracy L. Twinem, Benoit Ledoussal, Mark A. Nienaber, Kelly M. Makin, Siddhartha Roychoudhury, Chuiying Li

The in vitro development of resistance to the new nonfluorinated quinolones (NFQs; PGE 9262932, PGE 4175997, and PGE 9509924) was investigated in Staphylococcus aureus . At concentrations two times the MIC, step 1 mutants were isolated more frequentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd1c7fbc60b17f5024617f60e596d85
https://europepmc.org/articles/PMC90847/

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Activity of non-fluorinated quinolones (NFQs) against quinolone-resistant Escherichia coli and Streptococcus pneumoniae

Autor: Tracy L. Twinem, Siddhartha Roychoudhury, Eric J. McIntosh, Kelly M. Makin, Benoit Ledoussal, Carl E. Catrenich

Publikováno v: The Journal of antimicrobial chemotherapy. 48(1)

The newly developed 8-methoxy, non-fluorinated quinolones (NFQs) were studied to elucidate their enzyme inhibitory activity against wild-type and mutant GyrA (Ser-83-->Trp) forms of Escherichia coli DNA gyrase. Using a DNA supercoiling inhibition ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948cec15279885b6f9f6785cf67a5667
https://pubmed.ncbi.nlm.nih.gov/11418510

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