Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kelly M. Lohr"'
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue. Methods We combine gene
Externí odkaz:
https://doaj.org/article/3e887c836e68452cb7cb0277c6f49b02
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Tau is a microtubule-associated protein that stabilizes the neuronal cytoskeleton. In the family of neurodegenerative diseases known as tauopathies, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), and chronic traumatic encephalop
Externí odkaz:
https://doaj.org/article/2bd58d18ae3a4258b87a2935558ce5b4
Autor:
Christina Coughlan, Douglas I. Walker, Kelly M. Lohr, Jason R. Richardson, Laura M. Saba, W. Michael Caudle, Kristofer S. Fritz, James R. Roede
Publikováno v:
Parkinson's Disease, Vol 2015 (2015)
Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson’s disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigro
Externí odkaz:
https://doaj.org/article/5c27f4c0004748719f06089ac32b6a5c
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience
Tau is a microtubule-associated protein that stabilizes the neuronal cytoskeleton. In the family of neurodegenerative diseases known as tauopathies, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), and chronic traumatic encephalop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49535e282fbcb5b9e93a4e64ee83d76
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue. Methods We combine genetic analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70947797447037f8dc91f501bf8a938e
https://doi.org/10.1186/s13024-021-00454-3
https://doi.org/10.1186/s13024-021-00454-3
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 2, p e1009359 (2021)
PLoS Genetics, Vol 17, Iss 2, p e1009359 (2021)
Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson’s disease and related α-synucleinopathies. However, mechanisms mediating dysfunction of membrane tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46462d799a5a81edf98ce2bf189d9995
http://europepmc.org/articles/PMC7895402
http://europepmc.org/articles/PMC7895402
Publikováno v:
Proc Natl Acad Sci U S A
Mitochondrial and metabolic dysfunction are often implicated in neurological disease, but effective mechanism-based therapies remain elusive. We performed a genome-scale forward genetic screen in a Drosophila model of tauopathy, a class of neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce4294a40cb03dab58ccfc7e8b83d45
https://europepmc.org/articles/PMC7777082/
https://europepmc.org/articles/PMC7777082/
Autor:
Gary W. Miller, Tanja Jovanovic, William Ellsworth, Emily J. Winokur, Kelly M. Lohr, Rachel C Branco, Rohan K. Dhamsania, Jason P. Schroeder, David Weinshenker, Carlie A. Black, James P. Burkett
Publikováno v:
Genes Brain Behav
A subset of people exposed to a traumatic event develop post-traumatic stress disorder (PTSD), which is associated with dysregulated fear behavior. Genetic variation in SLC18A2, the gene that encodes vesicular monoamine transporter 2 (VMAT2), has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4209897636e8d955f5434622b2efee
https://europepmc.org/articles/PMC8170828/
https://europepmc.org/articles/PMC8170828/
Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice
Autor:
Amy R. Dunn, Thomas S. Guillot, Kelly M. Lohr, Kristen A. Stout, Rachel A. Cliburn, Shawn P. Alter, Gary W. Miller
Publikováno v:
ACS Chemical Neuroscience
Drugs of abuse induce sensitization, which is defined as enhanced response to additional drug following a period of withdrawal. Sensitization occurs in both humans and animal models of drug reinforcement and contributes substantially to the addictive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35751a5bbf873cd140de8c9fecd9a8b
https://doi.org/10.1021/acschemneuro.6b00131
https://doi.org/10.1021/acschemneuro.6b00131
Autor:
Xinglong Gu, Xian Lin, Gary W. Miller, Loukia Parisiadou, Jia Yu, Huaibin Cai, David M. Lovinger, Kelly M. Lohr, Carmelo Sgobio, Jinhui Ding, Lixin Sun, Yolanda Mateo, Namratha Sastry, Guoxiang Liu, Chengsong Xie
Publikováno v:
Human Molecular Genetics. 24:5299-5312
Preferential dysfunction/degeneration of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main movement symptoms manifested in Parkinson's disease (PD). Although the Leucine-rich repeat kinase 2 (LRRK2) G201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106f5774544b97415f852f2b6519a1d2
https://doi.org/10.1093/hmg/ddv249
https://doi.org/10.1093/hmg/ddv249