Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kelly M. Hines"'
Autor:
Kanupriya R. Daga, Andrew M. Larey, Maria G. Morfin, Kailin Chen, Sara Bitarafan, Jana M. Carpenter, Hannah M. Hynds, Kelly M. Hines, Levi B. Wood, Ross A. Marklein
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-21 (2024)
Abstract Background Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-EVs can interact with microglia, the resident immune cells of the brain, to exert their immunomodulatory effe
Externí odkaz:
https://doaj.org/article/ed07ae149d72409faf0f21728dc5d06e
Autor:
Andrew M. Larey, Thomas M. Spoerer, Kanupriya R. Daga, Maria G. Morfin, Hannah M. Hynds, Jana Carpenter, Kelly M. Hines, Ross A. Marklein
Publikováno v:
Bioactive Materials, Vol 37, Iss , Pp 153-171 (2024)
Due to their immunomodulatory function, mesenchymal stromal cells (MSCs) are a promising therapeutic with the potential to treat neuroinflammation associated with neurodegenerative diseases. This function is mediated by secreted extracellular vesicle
Externí odkaz:
https://doaj.org/article/117fb0ce6fda42fcb4c68978057c974e
Autor:
Christian D. Freeman, Tayte Hansen, Ramona Urbauer, Brian J. Wilkinson, Vineet K. Singh, Kelly M. Hines
Publikováno v:
mSphere, Vol 9, Iss 6 (2024)
ABSTRACT Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of
Externí odkaz:
https://doaj.org/article/2bb97e6d17eb40cd96a750ff86b94758
Publikováno v:
ACS Measurement Science Au, Vol 4, Iss 1, Pp 104-116 (2023)
Externí odkaz:
https://doaj.org/article/4ec2980513964335b0deafa4d3cb9e2b
Autor:
Rutan Zhang, Ismael A. Barreras Beltran, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Kelly M. Hines, Stephen J. Salipante, Libin Xu, Brian J. Werth
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Methicillin-resistant S. aureus (MRSA) are resistant to beta-lactams, but synergistic activity between beta-lactams and glycopeptides/lipopeptides is common. Many have attributed this synergy to the beta-lactam-glycopeptide seesaw effect; however, th
Externí odkaz:
https://doaj.org/article/86c6e3d5d65443a78816a56ddcd76caa
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
It has been suggested that daptomycin can be inactivated by lipids released by Staphylococcus aureus and that this effect is antagonized by phenol soluble modulins (PSMs), which bind to the shed lipids. PSM production is regulated by the Agr system,
Externí odkaz:
https://doaj.org/article/94e5bc1fe5ac407da20664dff787dc35
Autor:
Kelly M. Hines, Gloria Alvarado, Xi Chen, Craig Gatto, Antje Pokorny, Francis Alonzo, Brian J. Wilkinson, Libin Xu
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Staphylococcus aureus can incorporate exogenous straight-chain unsaturated and saturated fatty acids (SCUFAs and SCFAs, respectively) to replace some of the normally biosynthesized branched-chain fatty acids and SCFAs. In this study, the imp
Externí odkaz:
https://doaj.org/article/b40cd8a180f147d986720f52a69a8884
Autor:
Steven J. Fliesler, Neal S. Peachey, Josi Herron, Kelly M. Hines, Nadav I. Weinstock, Sriganesh Ramachandra Rao, Libin Xu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Smith-Lemli-Opitz Syndrome (SLOS) is a recessive human disease caused by defective cholesterol (CHOL) synthesis at the level of DHCR7 (7-dehydrocholesterol reductase), which normally catalyzes the conversion of 7-dehydrocholesterol (7DHC) to
Externí odkaz:
https://doaj.org/article/0f9352eaa4c44a5492915c722acf3157
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 809-819 (2017)
Ion mobility-mass spectrometry (IM-MS) has proven to be a highly informative technique for the characterization of lipids from cells and tissues. We report the combination of hydrophilic-interaction liquid chromatography (HILIC) with traveling-wave I
Externí odkaz:
https://doaj.org/article/1da644c23e81417c9c86065660c5b0a6
Autor:
Aurore Fleurie, Abdelrahim Zoued, Laura Alvarez, Kelly M. Hines, Felipe Cava, Libin Xu, Brigid M. Davis, Matthew K. Waldor
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT BolA family proteins are conserved in Gram-negative bacteria and many eukaryotes. While diverse cellular phenotypes have been linked to this protein family, the molecular pathways through which these proteins mediate their effects are not we
Externí odkaz:
https://doaj.org/article/33ca789961c04e5b83d94e3691620288