Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kelly M. Bush"'
Autor:
Kelly M. Bush, Rachel Herndon Klein, Nichole Lewis, Paul S. Knoepfler, Vanessa Cervantes, Mirna Lechpammer, Kuang Yui Chen, Aasim Naqvi, Angel M. Carcaboso
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Communications biology, vol 3, iss 1
Communications Biology
Communications biology, vol 3, iss 1
Communications Biology
Histone H3.3 mutations are a hallmark of pediatric gliomas, but their core oncogenic mechanisms are not well-defined. To identify major effectors, we used CRISPR-Cas9 to introduce H3.3K27M and G34R mutations into previously H3.3-wildtype brain cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf23000072b959b2350f5158849985bf
http://link.springer.com/article/10.1038/s42003-020-1076-0
http://link.springer.com/article/10.1038/s42003-020-1076-0
Publikováno v:
Neuro Oncol
Alterations in histone H3.3 are common driver mutations in high-grade pediatric gliomas, but the central oncogenic mechanisms remain an open question. To identify important mutant H3.3 effectors, we used CRISPR-Cas9 to precisely introduce H3.3 K27M a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04631b7d0324f7b9a07aff20e55eb40
https://europepmc.org/articles/PMC6847561/
https://europepmc.org/articles/PMC6847561/
Autor:
Vanessa Cervantes, Paul S. Knoepfler, Michael Chen, Angel M. Carcaboso, Aasim Naqvi, Nichole Lewis, Kelly M. Bush, Rachel Herndon Klein
Pediatric high-grade gliomas often contain mutations in the H3F3A gene encoding the histone variant H3.3 and more rarely in canonical histone H3 family genes, a feature distinguishing them from adult gliomas. To define specific functionally significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931b001a2f0ae191c9b7215b00bd6ac2
https://europepmc.org/articles/PMC6477327/
https://europepmc.org/articles/PMC6477327/
Autor:
Rebecca Cotterman, Bonnie L. Barrilleaux, Paul S. Knoepfler, Kelly M. Bush, Benjamin T. K. Yuen
Publikováno v:
Development. 141:3483-3494
The histone variant H3.3 is involved in diverse biological processes, including development, transcriptional memory and transcriptional reprogramming, as well as diseases, including most notably malignant brain tumors. Recently, we developed a knocko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73ffa05e6025ae3672e1992932b0e0e
https://doi.org/10.1242/dev.106450
https://doi.org/10.1242/dev.106450
Autor:
John W. Riggs, Bonnie L. Barrilleaux, Benjamin T. K. Yuen, Rebecca Cotterman, Henriette O'Geen, Kelly M. Bush, Paul S. Knoepfler
Publikováno v:
Bush, Kelly M; Yuen, Benjamin TK; Barrilleaux, Bonnie L; Riggs, John W; O’Geen, Henriette; Cotterman, Rebecca F; et al.(2013). Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics & Chromatin, 6(1), 7. doi: http://dx.doi.org/10.1186/1756-8935-6-7. Retrieved from: http://www.escholarship.org/uc/item/4c96g6pw
Epigenetics & Chromatin
Epigenetics & Chromatin
Background The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e771a9ac0487438db7c8782cffa3c17c
http://www.escholarship.org/uc/item/4c96g6pw
http://www.escholarship.org/uc/item/4c96g6pw
Autor:
Kelly M. Bush, John W. Riggs, Vanessa Chan, Bonnie L. Barrilleaux, Natasha Varlakhanova, Paul S. Knoepfler
Induced pluripotent stem cells (iPSCs) have the potential for creating patient-specific regenerative medicine therapies, but the links between pluripotency and tumorigenicity raise important safety concerns. More specifically, the methods employed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f874b0a2341c84d9fdde27f44eb92c74
https://europepmc.org/articles/PMC3528096/
https://europepmc.org/articles/PMC3528096/
Autor:
Paul S. Knoepfler, Kelly M. Bush
Publikováno v:
Disease Models & Mechanisms. 3:9-10
I [Paul Knoepfler] started working with mice as a postdoc at the Fred Hutchinson Cancer Research Center about a decade ago. The lab maintained hundreds of mice and I was responsible for more than 100 of them. The method we used to keep track of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b1718747e4316e6a24c9dd990ca538f
https://doi.org/10.1242/dmm.004770
https://doi.org/10.1242/dmm.004770