Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection

Autor: Neil J Scolding, Anastasia Georgievskaya, Kate J. Heesom, Kelly M Hares, Juliana Redondo, Pamela Sarkar, Steven Bailey, Kevin C Kemp, Claire M Rice

Publikováno v: Sarkar, P, Redondo, J, Hares, K M, Bailey, S, Georgievskaya, A, Heesom, K J, Kemp, K C, Scolding, N J & Rice, C M 2021, ' Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection ', Multiple Sclerosis Journal . https://doi.org/10.1177/13524585211060686

Background: Cell-based therapies for multiple sclerosis (MS), including those employing autologous bone marrow-derived mesenchymal stromal cells (MSC) are being examined in clinical trials. However, recent studies have identified abnormalities in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a14b578ae9c3cacd16bd9a36ffc4b3
https://pubmed.ncbi.nlm.nih.gov/34841955

shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

Autor: Kelly M Hares, Juliana Redondo, Andrew Herman, Helen L. Scott, Clare L Killick-Cole, Kevin C Kemp, Francesca Mills, Susan C Short, Risto A. Kauppinen, Gary Shaw, Alastair Wilkins, Lorena Sueiro Ballesteros, Heiko Wurdak, James B. Uney, Tom Batstone, Harry Bulstrode, William G B Singleton, Tim Brend, Kathreena M Kurian, Oscar Cordero-Llana, Harry R Haynes

Publikováno v: The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201

The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39bf5d26efe7fd0d11f188b4b54bded
http://europepmc.org/articles/PMC6462812

The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma

Autor: Krishnakumar Garadi, Clare L Killick-Cole, Alastair Wilkins, Juliana Redondo, Paul D. White, Harry R Haynes, Sam Guglani, Kelly M Hares, Kathreena M Kurian, Kevin C Kemp, William G B Singleton, Jonathan R Stevens

Publikováno v: Histopathology. 70:1030-1043

© 2016 John Wiley & Sons Ltd Aims: PPARα agonists are in current clinical use as hypolipidaemic agents and show significant antineoplastic effects in human glioblastoma models. To date however, the expression of PPARα in large-scale glioblastoma d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4375b68b222c536f8de2a3519bb163
https://doi.org/10.1111/his.13142

KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences

Autor: Neil J Scolding, Scott Miners, Kelly M Hares, Alastair Wilkins, Seth Love

Publikováno v: Hares, K M, Miners, S, Scolding, N, Love, S & Wilkins, A 2019, ' KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences ', AMRC Open Research, vol. 1, 1 . https://doi.org/10.12688/amrcopenres.12861.1

Background: Early disturbances in axonal transport, before the onset of gross neuropathology, occur in a spectrum of neurodegenerative diseases including Alzheimer’s disease. Kinesin superfamily motor proteins (KIFs) are responsible for anterograde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2421ec062855f8691109e9f76e45b332
https://research-information.bris.ac.uk/en/publications/709c1ad3-cad6-4a3e-af2c-40d171cf7d4b

Evaluation of the quality of RNA extracted from archival FFPE glioblastoma and epilepsy surgical samples for gene expression assays

Autor: Juliana Redondo, Karwan A. Moutasim, Clare L Killick-Cole, Kathreena M Kurian, Kevin C Kemp, Alastair Wilkins, Harry R Haynes, Kelly M Hares, Claire Faulkner

Publikováno v: Haynes, H R, Killick-Cole, C L, Hares, K M, Redondo, J, Kemp, K C, Moutasim, K A, Faulkner, C, Wilkins, A & Kurian, K M 2018, ' Evaluation of the quality of RNA extracted from archival FFPE glioblastoma and epilepsy surgical samples for gene expression assays ', Journal of Clinical Pathology, vol. 71, no. 8, pp. 695-701 . https://doi.org/10.1136/jclinpath-2017-204969

AimsHistopathological tissue samples are being increasingly used as sources of nucleic acids in molecular pathology translational research. This study investigated the suitability of glioblastoma and control central nervous system (CNS) formalin-fixe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9764cd310cba6c2d727ea7abcc846f
https://pubmed.ncbi.nlm.nih.gov/29463577