Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kelly M, Zatopek"'
Autor:
Leonardo Betancurt-Anzola, Markel Martínez-Carranza, Marc Delarue, Kelly M. Zatopek, Andrew F. Gardner, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (PolD)
Externí odkaz:
https://doaj.org/article/6fa735390f164ee1a07c249234ceecde
Autor:
Kelly M. Zatopek, Brett W. Burkhart, Richard D. Morgan, Alexandra M. Gehring, Kristin A. Scott, Thomas J. Santangelo, Andrew F. Gardner
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Thermococcus kodakarensis (T. kodakarensis), a hyperthermophilic, genetically accessible model archaeon, encodes two putative restriction modification (R-M) defense systems, TkoI and TkoII. TkoI is encoded by TK1460 while TkoII is encoded by TK1158.
Externí odkaz:
https://doaj.org/article/4131e7ff9cca4b30a7096adf843e5798
Autor:
Andrew F. Gardner, Kiserian M. Jackson, Madeleine M. Boyle, Jackson A. Buss, Vladimir Potapov, Alexandra M. Gehring, Kelly M. Zatopek, Ivan R. Corrêa Jr., Jennifer L. Ong, William E. Jack
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
A variant of 9°N DNA polymerase [Genbank ID (AAA88769.1)] with three mutations (D141A, E143A, A485L) and commercialized under the name “Therminator DNA polymerase” has the ability to incorporate a variety of modified nucleotide classes. This Rev
Externí odkaz:
https://doaj.org/article/dbab20a8f931428eabdea0cacf437dd8
Autor:
Guy Miezner, Israela Turgeman-Grott, Kelly M Zatopek, Andrew F Gardner, Leah Reshef, Deepak K Choudhary, Martina Alstetter, Thorsten Allers, Anita Marchfelder, Uri Gophna
Publikováno v:
microLife. 4
CRISPR-Cas systems provide heritable acquired immunity against viruses to archaea and bacteria. Cas3 is a CRISPR-associated protein that is common to all Type I systems, possesses both nuclease and helicase activities, and is responsible for degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f4b268a5f51bc572ba53569e2b62bb
https://doi.org/10.1093/femsml/uqad007
https://doi.org/10.1093/femsml/uqad007
Publikováno v:
Current Protocols. 2
The formation and persistence of DNA damage can impact biological processes such as DNA replication and transcription. To maintain genome stability and integrity, organisms rely on robust DNA damage repair pathways. Techniques to detect and locate DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8f524061699e6a6b8b2575c0d4f606
https://doi.org/10.1002/cpz1.595
https://doi.org/10.1002/cpz1.595
Autor:
Gregory J. S. Lohman, Léa Chuzel, Paul J Caffrey, Samantha L. Fossa, Andrew F. Gardner, Christopher H. Taron, Kelly M Zatopek, Katharina Bilotti, Alexandra M. Gehring
Publikováno v:
Applied and Environmental Microbiology. 88
It has been predicted that 30-80% of archaeal genomes remain annotated as hypothetical proteins with no assigned gene function. Further, many archaeal organisms are difficult to grow or are unculturable. To overcome these technical and experimental h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27adbff95b4f72a3446ea9134c5bf96c
https://doi.org/10.1128/aem.02137-21
https://doi.org/10.1128/aem.02137-21
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (21), pp.12204-12218. ⟨10.1093/nar/gkaa986⟩
Nucleic Acids Research, 2020, 48 (21), pp.12204-12218. ⟨10.1093/nar/gkaa986⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (21), pp.12204-12218. ⟨10.1093/nar/gkaa986⟩
Nucleic Acids Research, 2020, 48 (21), pp.12204-12218. ⟨10.1093/nar/gkaa986⟩
Family D DNA polymerase (PolD) is the essential replicative DNA polymerase for duplication of most archaeal genomes. PolD contains a unique two-barrel catalytic core absent from all other DNA polymerase families but found in RNA polymerases (RNAPs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fbf1b87ad50a09fe8aa5c33da49784
https://hal-pasteur.archives-ouvertes.fr/pasteur-03086156/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03086156/document
Autor:
Lisa L. Maduzia, Kelly M Zatopek, Jennifer L. Ong, Lixin Chen, Vladimir Potapov, Thomas C. Evans, Ece Alpaslan, Andrew F. Gardner, Laurence Ettwiller
Publikováno v:
DNA repair. 80
RAre DAmage and Repair sequencing (RADAR-seq) is a highly adaptable sequencing method that enables the identification and detection of rare DNA damage events for a wide variety of DNA lesions at single-molecule resolution on a genome-wide scale. In R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd18cb45b544aa2a7b3c29fab396bc5
https://pubmed.ncbi.nlm.nih.gov/31247470
https://pubmed.ncbi.nlm.nih.gov/31247470
Autor:
William E. Jack, Madeleine M. Boyle, Jackson Buss, Alexandra M. Gehring, Vladimir Potapov, Andrew F. Gardner, Kelly M Zatopek, Jennifer L. Ong, Kiserian M. Jackson, Ivan R. Corrêa
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
A variant of 9°N DNA polymerase [Genbank ID (AAA88769.1)] with three mutations (D141A, E143A, A485L) and commercialized under the name “Therminator DNA polymerase” has the ability to incorporate a variety of modified nucleotide classes. This Rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220e6e69a076ed397f0471d5e849461a
https://doi.org/10.3389/fmolb.2019.00028
https://doi.org/10.3389/fmolb.2019.00028
Autor:
Andrew F. Gardner, Thomas J. Santangelo, Vladimir Potapov, Brett W. Burkhart, Kelly M Zatopek, Alexandra M. Gehring
Publikováno v:
DNA repair
Reactive oxygen species drive the oxidation of guanine to 8-oxoguanine (8oxoG), which threatens genome integrity. The repair of 8oxoG is carried out by base excision repair enzymes in Bacteria and Eukarya, however, little is known about archaeal 8oxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31daa7e47c5306002debab87e49b915d
https://doi.org/10.1016/j.dnarep.2019.102767
https://doi.org/10.1016/j.dnarep.2019.102767