Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kelly Lau"'
Autor:
Kathryn S. Patton, M. Travis Harrison, Brian R. Long, Kelly Lau, Jennifer Holcomb, Rachel Owen, Theresa Kasprzyk, Sylvia Janetzki, Stephen J. Zoog, Christian Vettermann
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 183-195 (2021)
Adeno-associated virus (AAV)-based gene therapies have recently shown promise as a novel treatment for hereditary diseases. Due to the viral origin of the vector capsid, however, cellular immune response may be elicited that could eliminate transduce
Externí odkaz:
https://doaj.org/article/5e48ac7026a44118bcc0c85ea7d1de7a
Autor:
Soumi Gupta, Kelly Lau, Cary O. Harding, Gillian Shepherd, Ryan Boyer, John P. Atkinson, Vijaya Knight, Joy Olbertz, Kevin Larimore, Zhonghu Gu, Mingjin Li, Orli Rosen, Stephen J. Zoog, Haoling H. Weng, Becky Schweighardt
Publikováno v:
EBioMedicine, Vol 37, Iss , Pp 366-373 (2018)
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safe
Externí odkaz:
https://doaj.org/article/35d18890af2c449283e0ae76ff18ae3e
Autor:
Travis J Eisemann, Frederick Allen, Kelly Lau, Gregory R Shimamura, Philip D Jeffrey, Frederick M Hughson
Publikováno v:
eLife, Vol 9 (2020)
Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to
Externí odkaz:
https://doaj.org/article/e9c0b28703b047e99878b8ee5f275565
Autor:
Nicola Longo, Roberto Zori, Melissa P. Wasserstein, Jerry Vockley, Barbara K. Burton, Celeste Decker, Mingjin Li, Kelly Lau, Joy Jiang, Kevin Larimore, Janet A. Thomas
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Deficiency of phenylalanine hydroxylase causes phenylketonuria (PKU) with elevated phenylalanine (Phe) levels and associated neuropsychiatric and neurocognitive symptoms. Pegvaliase (PEGylated phenylalanine ammonia lyase) is an in
Externí odkaz:
https://doaj.org/article/c19eeaf6daa346a4a69eed3c82238591
Autor:
Yi A. Chen, Mark W. Kankel, Sam Hana, Shukkwan Kelly Lau, Maria I. Zavodszky, Olivia McKissick, Nicole Mastrangelo, Jessica Dion, Bin Wang, Daniel Ferretti, David Koske, Sydney Lehman, Kathryn Koszka, Helen McLaughlin, Mei Liu, Eric Marshall, Attila J. Fabian, Patrick Cullen, Galina Marsh, Stefan Hamann, Michael Craft, Jennifer Sebalusky, H. Moore Arnold, Rachelle Driscoll, Adam Sheehy, Yi Luo, Sonia Manca, Thomas Carlile, Chao Sun, Kirsten Sigrist, Alexander McCampbell, Christopher E. Henderson, Shih-Ching Lo
Publikováno v:
Gene Therapy. 30:443-454
CRISPR-based gene editing technology represents a promising approach to deliver therapies for inherited disorders, including amyotrophic lateral sclerosis (ALS). Toxic gain-of-function superoxide dismutase 1 (SOD1) mutations are responsible for ~20%
Autor:
Karen Gu, Kelly Lau, Huiyu Zhou, Johanna Abend, Stephen J. Zoog, Ryan Boyer, Joy Olbertz, Soumi Gupta, Madhukar Aryal, Kevin Larimore
Publikováno v:
Molecular Genetics and Metabolism. 134:235-242
Pegvaliase (Palynziq®) is an enzyme substitution therapy using PEGylated recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) to reduce blood phenylalanine (Phe) levels in adults with phenylketonuria (PKU). In Phase 3 clinical studies,
Autor:
Juliette Salles, Antoine Yrondi, Fouad Marhar, Nicolas Andant, Raimundo Avilés Dorlhiac, Binh Quach, Jiao Jiao, Samuel Antunes, Ukadike Chris Ugbolue, Julien Guegan, Karine Rouffiac, Bruno Pereira, The COVISTRESS Network, Maélys Clinchamps, Stéphanie Mestres, Cécile Miele, Valentin Navel, Lénise Parreira, Yves Boirie Jean-Baptiste Bouillon-Minois, Martine Duclos Maria Livia Fantini, Jeannot Schmidt, Stéphanie Tubert-Jeannin, Mickael Berthon, Pierre Chausse, Michael Dambrun, Sylvie Droit-Volet, Serge Guimond, Laurie Mondillon, Armelle Nugier, Pascal Huguet, Samuel Dewavrin, Geraldine Naughton, Amanda Benson, Claus Lamm, Karen Gbaglo, Vicky Drapeau, Benjamin Bustos, Gu Yaodong, Haifeng Zhang, Peter Dieckmann, Julien Baker, Yanping Duan, Gemma Gao, Wendy Y J Huang, Ka Lai Kelly Lau, Chun-Qing Zhang, Perluigi Cocco, Rosamaria Lecca, Monica Puligheddu, Michela Figorilli, Morteza Charkhabi, Reza Bagheri, Daniela Pfabigan, David Neto, Pedro Almeida, Maria João Gouveia, Pedro Quinteiro, Constanta Urzeala, Benoit Dubuis, Juliette Lemaignen, Andy Liu, Foued Saadaoui, Keri Kulik, Kuan-chou Chen
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Frontiers, 2021, 12, pp.689634. ⟨10.3389/fpsyt.2021.689634⟩
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry, 2021, 12, pp.689634. ⟨10.3389/fpsyt.2021.689634⟩
Frontiers in Psychiatry, Frontiers, 2021, 12, pp.689634. ⟨10.3389/fpsyt.2021.689634⟩
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry, 2021, 12, pp.689634. ⟨10.3389/fpsyt.2021.689634⟩
International audience; Introduction: COVID-19 lockdown measures have been sources of both potential stress and possible psychological and addiction complications. A lack of activity and isolation during lockdown are among the factors thought to be b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9b32c32f89763e132688bd65fbda34
https://hal.archives-ouvertes.fr/hal-03483224/file/fpsyt-12-689634.pdf
https://hal.archives-ouvertes.fr/hal-03483224/file/fpsyt-12-689634.pdf
Autor:
Nina Mitchell, Wing Yen Wong, Federico Mingozzi, M. Benjamin Hock, Kelly Lau, Romain Hardet, Mingjin Li, Brian Long, Klaudia Kuranda, Stephen J. Zoog, Gregory M. Hayes, Becky Schweighardt, Christian Vettermann, Philippe Veron
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2021, 29 (2), pp.597-610. ⟨10.1016/j.ymthe.2020.12.008⟩
Molecular Therapy, 2021, 29 (2), pp.597-610. ⟨10.1016/j.ymthe.2020.12.008⟩
Molecular Therapy, Cell Press, 2021, 29 (2), pp.597-610. ⟨10.1016/j.ymthe.2020.12.008⟩
Molecular Therapy, 2021, 29 (2), pp.597-610. ⟨10.1016/j.ymthe.2020.12.008⟩
Evaluation of immune responses to adeno-associated virus (AAV)-mediated gene therapies prior to and following dose administration plays a key role in determining therapeutic safety and efficacy. This report describes up to 3 years of immunogenicity d
Autor:
Kelly Lau, Teck Hong Tan
Publikováno v:
Open House International. 46:81-95
PurposeThe purpose of this paper is to address the knowledge gap by analysing the motivations of driving both users and hosts to the co-working space in Kuala Lumpur, Malaysia as the motives of co-working space is related to how well that space suppo
Autor:
Pal Investigators, Barbara K. Burton, Celeste Decker, Dorothy K. Grange, Cary O. Harding, Jerry Vockley, Kelly Lau, Orli Rosen, Janet A. Thomas, Nicola Longo, Mingjin Li, Pal, Kevin Larimore
Publikováno v:
Molecular Genetics and Metabolism. 130:239-246
Background Phenylketonuria (PKU) is characterized by a deficiency in phenylalanine hydroxylase (PAH) that may lead to elevated blood phenylalanine (Phe) and significant neurocognitive and neuropsychological comorbidities. Pegvaliase (PALYNZIQ®, BioM