Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kelly L. Savage"'
Autor:
Vanessa L. Sherman, M. Reza Anari, Catherine M. Wiscount, Julie A. Krueger, Christopher J. Kochansky, Bobby J. Lucas, Tran Lekhanh O, Joseph P. Vacca, Terry A. Lyle, Bradley K. Wong, Sanderson Philip E, Heidi L. Shimp, Peter D. Williams, Sean Yu, Donnette D. Staas, Kelly L. Savage, S. Dale Lewis, Rebecca B. White, Youwei Yan, Daniel R. McMasters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6900-6916
Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1 position. Using these as lead compounds for further optimization, we identified sites of me
Autor:
Dennis L. Bohn, Sanderson Philip E, Bobby J. Lucas, Adel M. Naylor-Olsen, Julie A. Krueger, Elizabeth A. Lyle, Franklin C. Clayton, Youwei Yan, S. Dale Lewis, Denise J. Bickel, Denice C. Welsh, Kellie J. Cutrona, Audrey A. Wallace, Kelly L. Savage
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1441-1444
We describe a series of highly potent and efficacious thrombin inhibitors based on a 3-amino-4-sulfonylpyridinone acetamide template. The functionally dense sulfonyl group stabilizes the aminopyridinone, conformationally constrains the 4-substituent,
Publikováno v:
ChemInform. 34
Addition of the Reformatsky reagent derived from ethyl bromodifluoroacetate to alkyl- and aryl-substituted N-tert-butylsulfinimines furnishes beta-tert-butylsulfinamyl-beta-substituted alpha,alpha-difluoroproponiates in diastereomeric ratios ranging
Autor:
Bobby J. Lucas, Sanderson Philip E, Adel M. Naylor-Olsen, William M. Sanders, Youwei Yan, Terry A. Lyle, Joseph J. Lynch, Kelly L. Savage, Matthew G. Stanton, Julie A. Krueger, Colleen M. McDonough, Bruce D. Dorsey, S. Dale Lewis
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(5)
Starting from a 2-amino-6-methylpyridine P1 group and following a strategy of enlarging it whilst reducing its polarity, we have developed a series of potent, moderately basic azaindoles which are intrinsically much more selective for thrombin versus