Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kelly L. McGuire"'
Autor:
Alexander R. Nectow, Maria V. Moya, Mats I. Ekstrand, Awni Mousa, Kelly L. McGuire, Caroline E. Sferrazza, Bianca C. Field, Gabrielle S. Rabinowitz, Kirsty Sawicka, Yupu Liang, Jeffrey M. Friedman, Nathaniel Heintz, Eric F. Schmidt
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 655-667 (2017)
Summary: Translational profiling methodologies enable the systematic characterization of cell types in complex tissues, such as the mammalian brain, where neuronal isolation is exceptionally difficult. Here, we report a versatile strategy for profili
Externí odkaz:
https://doaj.org/article/74f62f4da03d43449f074752f896fc74
Mechanism and Kinetics of Copper Complexes Binding to the Influenza A M2 S31N and S31N/G34E Channels
Autor:
Daniel H. Ess, Jonathan T. Hill, David D. Busath, Roger G. Harrison, Phillip Smit, Kelly L. McGuire
Publikováno v:
Biophys J
Copper(II) is known to bind in the influenza virus His37 cluster in the homotetrameric M2 proton channel and block the proton current needed for uncoating. Copper complexes based on iminodiacetate also block the M2 proton channel and show reduced cyt
Publikováno v:
Biophys J
The ubiquitous mutation from serine (WT) to asparagine at residue 31 (S31N) in the influenza A M2 channel renders it insensitive to amantadine (AMT) and rimantadine (RMT) block, but it is unknown whether the inhibition results from weak binding or in
Publikováno v:
Journal of visualized experiments : JoVE. (180)
Imaging biological specimens with electrons for high-resolution structure determination by single-particle cryogenic electron microscopy (cryoEM) requires a thin layer of vitreous ice containing the biomolecules of interest. Despite numerous technolo
Autor:
Kelly L. McGuire, Oren Amsalem, Arthur U. Sugden, Rohan N. Ramesh, Jesseba Fernando, Christian R. Burgess, Mark L. Andermann
Publikováno v:
Current biology : CB. 32(7)
Postrhinal cortex (POR) and neighboring lateral visual association areas are necessary for identifying objects and interpreting them in specific contexts, but how POR neurons encode the same object across contexts remains unclear. Here, we imaged exc
Autor:
Daniel H. Ess, Jonathon T. Hill, Roger G. Harrison, P. Smit, Kelly L. McGuire, David D. Busath
Copper(II) is known to bind in the influenza virus His37 cluster in the homotetrameric M2 proton channel and block the proton current needed for uncoating. Copper complexes based on iminodiacetate also block the M2 proton channel and show reduced cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::265a84ed16350e473919c89c08551d56
https://doi.org/10.1101/2020.08.24.265165
https://doi.org/10.1101/2020.08.24.265165
Autor:
Jun Wang, David D. Busath, Kelly L. McGuire, Natalie A. Fokina, Peter R. Schreiner, Panagiotis Lagarias, Anja Hoffmann, Athina Konstantinidi, Antonios Kolocouris, Chunlong Ma, Ioannis Papanastasiou, Christina Tzitzoglaki, Santiago Vázquez, Michaela Schmidtke
Publikováno v:
ACS Chem Biol
Dipòsit Digital de la UB
Universidad de Barcelona
ACS Chemical Biology
Dipòsit Digital de la UB
Universidad de Barcelona
ACS Chemical Biology
We report on using the synthetic aminoadamantane-CH2-aryl derivatives 1-6 as sensitive probes for blocking M2 S31N and influenza A virus (IAV) M2 wild-type (WT) channels as well as virus replication in cell culture. The binding kinetics measured usin
Autor:
Stephen Facer, Nicole Nelson, Jon Hogge, Austin Brown, Roger G. Harrison, Steven Walker, Nathan Liddle, Aidan J. Hintze, Jordan R. Pollock, Johnny Lynch, David D. Busath, Kelly L. McGuire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da86c3687c26a628b7db9afba8730d7c
https://doi.org/10.5772/intechopen.88786
https://doi.org/10.5772/intechopen.88786
Autor:
Kelly L. McGuire, Michaela Schmidtke, Anja Hoffmann, Antonios Kolocouris, Christina Tzitzoglaki, Schreiner Pr, Busath D, Papanastasiou I, Jun Wang, Santiago Vázquez, Fokina Na, Athina Konstantinidi, Panagiotis Lagarias
In an attempt to synthesize potent blockers of the influenza A M2 S31N proton channel with modifications of amantadine, we used MD simulations and MM-PBSA calculations to project binding modes of compounds 2-5, which are analogues of 1, a dual blocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c55a4500eea7215de924342a0cd1f37
https://doi.org/10.26434/chemrxiv.11494170
https://doi.org/10.26434/chemrxiv.11494170
Autor:
Anja Hoffmann, David D. Busath, Michaela Schmidtke, Dimitrios Kolokouris, Johanna Hutterer, Jun Wang, Kelly L. McGuire, Kathrin Freudenberger, Antonios Drakopoulos, Christina Tzitzoglaki, Günter Gauglitz, Chunlong Ma, Athina Konstantinidi, Antonios Kolocouris
Publikováno v:
ACS Medicinal Chemistry Letters. 9:198-203
[Image: see text] Recently, the binding kinetics of a ligand–target interaction, such as the residence time of a small molecule on its protein target, are seen as increasingly important for drug efficacy. Here, we investigate these concepts to expl