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Autor:
Jerome F. Baker, Kelly L. Dauer, Nicholas J. Karney, Mary C. O’Sullivan, Hannah E. Valdes, Andrew C. Forrestel, Cyrus J. Bacchi, Timothy B. Durham
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:996-1010
Trypanothione reductase (TR) is an enzyme critical to the maintenance of the thiol redox balance in trypanosomatids, including the genera Trypanosoma and Leishmania that are parasites responsible for several serious diseases. Analogs of clomipramine