Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kelly L. Arnett"'
Autor:
Sue Felton, Xiaomei Gao, Diane L. Fairclough, Jean S. Kutner, Robert M. Arnold, Kathryn I. Pollak, Kelly L. Arnett
Publikováno v:
Journal of pain and symptom management. 59(4)
Context Palliative care clinicians often have challenging conversations with patients or family caregivers who express ambivalence about goals or feel reluctant to discuss topics. Motivational Interviewing (MI) has tools to address ambivalence and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd8bf71c74e820b2d701b8eb4e886d4
https://pubmed.ncbi.nlm.nih.gov/31765759
https://pubmed.ncbi.nlm.nih.gov/31765759
Publikováno v:
American Journal of Hospice and Palliative Medicine®. 34:946-953
Background: Interprofessional health care team members consider advance care planning (ACP) to be important, yet gaps remain in systematic clinical routines to support ACP. A clearer understanding of the interprofessional team members’ perspectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1a3404157816ac6fb6a9355bacb8cc
https://doi.org/10.1177/1049909116666358
https://doi.org/10.1177/1049909116666358
Publikováno v:
Targeting Notch in Cancer ISBN: 9781493988570
The conserved Notch signaling pathway plays a central role in development and adult tissue homeostasis. Notch signaling is initiated by binding to a transmembrane ligand. E3 ubiquitin ligase-mediated ligand endocytosis enables release of the negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21045ff913d6946337e0109900bebe38
https://doi.org/10.1007/978-1-4939-8859-4_1
https://doi.org/10.1007/978-1-4939-8859-4_1
Autor:
Warren S. Pear, X. Shirley Liu, Hudan Liu, Eric Allan Severson, Hongfang Wang, Stephen C. Blacklow, Jon C. Aster, Chongzhi Zang, Kelly L. Arnett, Len Taing
Publikováno v:
Science signaling. 10(477)
Notch transcription complexes (NTCs) drive target gene expression by binding to two distinct types of genomic response elements, NTC monomer–binding sites and sequence-paired sites (SPSs) that bind NTC dimers. SPSs are conserved and have been linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36abe887923523cfb7161ae40feb969
https://pubmed.ncbi.nlm.nih.gov/28465412
https://pubmed.ncbi.nlm.nih.gov/28465412
Autor:
X. Shirley Liu, Hongfang Wang, Chongzhi Zang, Len Taing, Warren S. Pear, Kelly L. Arnett, Jon C. Aster, Yinling Joey Wong, Stephen C. Blacklow
Publikováno v:
Proceedings of the National Academy of Sciences. 111:705-710
The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7aad23ff401104558a1a04e7732e2f
https://doi.org/10.1073/pnas.1315023111
https://doi.org/10.1073/pnas.1315023111
Autor:
Jon C. Aster, Hongfang Wang, Elliott Kieff, James Zou, Bradley E. Bernstein, Bo Zhao, Hoifung Wong, Todd Ashworth, Warren S. Pear, Jonathan Schug, Stephen C. Blacklow, Eric Johannsen, Kelly L. Arnett
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14908-14913
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human and murine T-lymphoblastic leukemia (TLL) genomes Notch1 binds preferentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500b1f59ae4120d6e1d1fab0ef5b1fcb
https://doi.org/10.1073/pnas.1109023108
https://doi.org/10.1073/pnas.1109023108
Autor:
Matthew R. Hass, Ma. Xenia G. Ilagan, Debbie G. McArthur, Jon C. Aster, Kelly L. Arnett, Stephen C. Blacklow, Raphael Kopan
Publikováno v:
Nature Structural & Molecular Biology. 17:1312-1317
Ligand-induced proteolysis of Notch produces an intracellular effector domain that transduces essential signals by regulating the transcription of target genes. This function relies on the formation of transcriptional activation complexes that includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7923ed2aa93d9eb1a86d5022d384f
https://doi.org/10.1038/nsmb.1938
https://doi.org/10.1038/nsmb.1938
Autor:
Lanwei Xu, Kelly L. Arnett, Mark Y. Chiang, Warren S. Pear, Jon C. Aster, Olga Shestova, Yue-Ming Li, Hongfang Wang, Avinash Bhandoola, Stephen C. Blacklow, Hudan Liu, Anthony W. S. Chi
Publikováno v:
Genes & Development. 24:2395-2407
Notch signaling regulates myriad cellular functions by activating transcription, yet how Notch selectively activates different transcriptional targets is poorly understood. The core Notch transcriptional activation complex can bind DNA as a monomer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5811365ec3caaf37cf1a6f7377742c49
https://doi.org/10.1101/gad.1975210
https://doi.org/10.1101/gad.1975210
Publikováno v:
Journal of Cell Science. 121:3109-3119
The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-cell communication in metazoan organisms, and has a central role both in development and in adult tissue homeostasis. Here, we summarize structural and biochemical ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea982e4b2a98c34b6f82dc9ec541068
https://doi.org/10.1242/jcs.035683
https://doi.org/10.1242/jcs.035683
Autor:
Stephen A. Liebhaber, Claudia Lanauze, Bradley E. Bernstein, Jonathan Schug, Yumi Yashiro-Ohtani, Will Bailis, Sujun Chen, Kelly L. Arnett, Birgit Knoechel, Yugong Ho, Jon C. Aster, Lumena Louis, Stephen C. Blacklow, Xiaole Shirley Liu, Katherine S. Forsyth, Warren S. Pear, Yoonjie Chung, Hongfang Wang, Chongzhi Zang, Gerd A. Blobel
Publikováno v:
Proceedings of the National Academy of Sciences. 111
Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in normal and malignant pre-T cells, but how Notch regulates Myc is unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ea6ae9d0cba51ca2b27daed78c3d2d
https://doi.org/10.1073/pnas.1407079111
https://doi.org/10.1073/pnas.1407079111