Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Kelly L. Jordan‐Sciutto"'
Autor:
Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Common single-nucleotide variants (SNVs) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) slightly increase the risk of disorders in the periphery and the central nervous system. EIF2AK3 encodes protein kinase RNA-like
Externí odkaz:
https://doaj.org/article/cd849f67507748ea9342ece45a821b3e
Autor:
Emma LaNoce, Daniel Y. Zhang, Alan Garcia-Epelboim, Yijing Su, Yusha Sun, Giana Alepa, Angelina R. Angelucci, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto, Hongjun Song, Guo-li Ming, Kimberly M. Christian
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionFor many therapeutic drugs, including antiretroviral drugs used to treat people living with HIV-1 (PLWH), we have little data on the potential effects on the developing human brain due to limited access to tissue and historical constraint
Externí odkaz:
https://doaj.org/article/474d3437c0cf49128cbae36e4c3182d6
Autor:
Alexander Starr, Emily Nickoloff-Bybel, Razan Abedalthaqafi, Naela Albloushi, Kelly L. Jordan-Sciutto
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
The central nervous system encounters a number of challenges following HIV infection, leading to increased risk for a collection of neurocognitive symptoms clinically classified as HIV-associated neurocognitive disorders (HAND). Studies attempting to
Externí odkaz:
https://doaj.org/article/e473f542c83a4bd1a7653ef9f938e261
Autor:
Hubert Monnerie, Micah Romer, Lindsay M. Roth, Caela Long, John S. Millar, Kelly L. Jordan-Sciutto, Judith B. Grinspan
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs). White matter damage persists
Externí odkaz:
https://doaj.org/article/d47bdc2e2ecf4e7fa6028db6e43612a6
Autor:
Lindsay K. Festa, Abigail E. Clyde, Caela C. Long, Lindsay M. Roth, Judith B. Grinspan, Kelly L. Jordan-Sciutto
Publikováno v:
Journal of Neurochemistry. 165:722-740
White matter deficits are a common neuropathologic finding in neurologic disorders, including HIV-associated neurocognitive disorders (HAND). In HAND, the persistence of white matter alterations despite suppressive antiretroviral (ARV) therapy sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a627b9f0ccd03847835bb156834cba07
https://doi.org/10.1111/jnc.15773
https://doi.org/10.1111/jnc.15773
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100190- (2020)
Summary: This protocol establishes a tri-culture of hiPSC-derived neurons, astrocytes, and microglia for the study of cellular interactions during homeostasis, injury, and disease. This system allows for mechanistic studies that can identify the role
Externí odkaz:
https://doaj.org/article/0927d346b1b54b6d8a250dfb0f3862a5
Autor:
Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Michelle A. Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L. Jordan-Sciutto, Yuri Persidsky
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Secoisolariciresinol diglucoside (SDG), the main lignan in flaxseed, is known for its beneficial effects in inflammation, oxidative stress, heart disease, tumor progression, atherosclerosis, and diabetes. SDG might be an attractiv
Externí odkaz:
https://doaj.org/article/a918e93c4b404fd39483221f2df263a6
Publikováno v:
Viruses, Vol 13, Iss 7, p 1242 (2021)
The persistence of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) in the era of effective antiretroviral therapy suggests that modern HIV neuropathogenesis is driven, at least in part, by mechanisms distinct from the
Externí odkaz:
https://doaj.org/article/4602a9a3cd6047788e4a5205d42400cc
Autor:
Sana Haddadi, Kelly L. Jordan-Sciutto, Cagla Akay-Espinoza, David Grelotti, Scott L. Letendre, Bin Tang, Ronald J. Ellis
Publikováno v:
Journal of neurology and psychology, vol 10, iss 1
Background. Depression is a debilitating and difficult-to-treat condition in people with HIV (PWH) despite viral suppression on antiretroviral therapy (ART). Depression is associated with activation of the PKR-like ER kinase (PERK) pathway, which reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902b5a320b8a6d9faf7af3c2d53ab05a
https://escholarship.org/uc/item/4xb6j7c1
https://escholarship.org/uc/item/4xb6j7c1
Autor:
Aidan T. Pezacki, Carson D. Matier, Xingxing Gu, Eric Kummelstedt, Sarah E. Bond, Laura Torrente, Kelly L. Jordan-Sciutto, Gina M. DeNicola, Timothy A. Su, Donita C. Brady, Christopher J. Chang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 43
Copper is an essential metal nutrient for life that often relies on redox cycling between Cu(I) and Cu(II) oxidation states to fulfill its physiological roles, but alterations in cellular redox status can lead to imbalances in copper homeostasis that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8c70a9e13add0b71c8d4b433eab0fe
https://escholarship.org/uc/item/46t2n72s
https://escholarship.org/uc/item/46t2n72s