Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kelly Kaihara"'
Autor:
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentage
Externí odkaz:
https://doaj.org/article/5dde8cd7955f4749b3113f29084ac913
Autor:
Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue com
Externí odkaz:
https://doaj.org/article/5cffcfe0ec4f4e7591dee537d4620c0d
Autor:
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Emilia Mazza, Simone Puccio, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza
Immune checkpoint inhibitors that maintain anti-tumor T cell response are used for treating patients with metastatic melanoma. Since the response to treatment is extremely variable, biomarkers are urgently needed to identify patients who could benefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29910b1475dce18cb4f280a85eb88269
https://doi.org/10.21203/rs.3.rs-84729/v1
https://doi.org/10.21203/rs.3.rs-84729/v1
Autor:
Shannan J. Ho Sui, Anthony Martin, Kelly Kaihara, Karenina Sanders, Gregory Humphrey, Jacob E. Moskowitz, J.R. Caldera, Phillip Fleshner, Michael J. Steinbaugh, Matthew J. Brady, Huiying Li, Rob Knight, Yasiru Ratnayake, Connie W.Y. Ha, Kelvin S.L. Chan, Yizhou Wang, Kenneth Gouin, Suzanne Devkota, Dermot P.B. McGovern, David M. Underhill, Baochen Shi, Simon R.V. Knott, Gustaf Hendrick, Shaohong Yang, Christian Arias, Gregory D. Sepich-Poore
Publikováno v:
Cell, vol 183, iss 3
Cell
Cell
A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7219b3daf27e9204d94d5a10e88a898b
https://escholarship.org/uc/item/0rb2r6q2
https://escholarship.org/uc/item/0rb2r6q2
Autor:
Dominic Grün, Johannes W. Bagnoli, Catia Moutinho, Xian Adiconis, Atefeh Lafzi, Christoph Ziegenhain, Yasha Talaga, Kaori Tanaka, Ivo Gut, Adrián Álvarez-Varela, Cornelius Fischer, Tetsutaro Hayashi, Lucas E. Wange, Oliver Stegle, Joshua Z. Levin, Chad Sanada, Yohei Sasagawa, Stéphane C. Boutet, Sascha Sauer, Chris Brampton, Christian Conrad, Eduard Batlle, Kelly Kaihara, Davis J. McCarthy, Caroline Braeuning, Julia K. Lau, Itoshi Nikaido, Aik Ooi, Sagar, Holger Heyn, Swati Parekh, Aviv Regev, Marta Gut, Elisabetta Mereu, Wolfgang Enard, Timo Trefzer, Robert C. Jones, Lan T. Nguyen, Rickard Sandberg, Aleksandar Janjic
Publikováno v:
Nature Biotechnology
Nat Biotechnol
Nat Biotechnol
Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being used to compile cell atlases of tissues, orga
Publikováno v:
Islets. 8:125-134
Type 2 diabetes is associated with obesity, insulin resistance and β-cell failure. Therapeutic aims are to reduce adiposity, improve insulin sensitivity and enhance β-cell function. However, it has been proposed that chronically increasing insulin
Autor:
Lorna M. Dickson, Barton Wicksteed, Kelly Kaihara, Johanne H. Ellenbroek, Brian T. Layden, Caitlin M.D. Orr
Publikováno v:
Diabetes
Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic p
Autor:
Michael W. Roe, Lorna M. Dickson, Natalia A. Tamarina, David A. Jacobson, Louis H. Philipson, Barton Wicksteed, Kelly Kaihara
Publikováno v:
Diabetes
Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phas
Publikováno v:
Genetic Engineering & Biotechnology News. 37:12-13
Autor:
Martin J. Lohse, Luis R. Landa, Kajorn Kitiphongspattana, George G. Holz, Mark C. Harbeck, Oleg G. Chepurny, Kelly Kaihara, Oliver Graf, Viacheslav O. Nikolaev, Michael W. Roe
Publikováno v:
Journal of Biological Chemistry. 280:31294-31302
Ca2+ and cAMP are important second messengers that regulate multiple cellular processes. Although previous studies have suggested direct interactions between Ca2+ and cAMP signaling pathways, the underlying mechanisms remain unresolved. In particular