Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kelly J. Powell"'
Publikováno v:
Neuroscience. 144:1-7
Recognition memory was assessed in adult rats that received bilateral injections of saline (sham lesions) or ibotenic acid (lesioned) in the ventral hippocampus as neonates (postnatal day 7, PD7) or young adult (42 days of age, PD42) using the Novel
Autor:
Tammy L Binder, Yusaku Nakabeppu, Daniel R. Weinberger, Kelly J. Powell, Barbara K. Lipska, George S. Robertson, Sarah E. Hori
Publikováno v:
Neuropsychopharmacology. 31:700-711
Rats that have sustained bilateral excitotoxic lesions of the ventral hippocampus (VH) as neonates develop behavioral abnormalities as adults (hyper-responsiveness to stress, diminished prepulse inhibition, and increased sensitivity to dopamine agoni
Autor:
Asha Jhamandas, Noura S. Abul-Husn, Mary C. Olmstead, Kelly J. Powell, Richard J. Beninger, Khem Jhamandas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:588-596
Opioid agonists such as morphine have been found to exert excitatory and inhibitory receptor-mediated effects at low and high doses, respectively. Ultra-low doses of opioid antagonists (naloxone and naltrexone), which selectively inhibit the excitato
Publikováno v:
European Journal of Neuroscience. 14:1091-1104
Tolerance to opiates reduces their effectiveness in the treatment of severe pain. Although the mechanisms are unclear, overactivity of pro-nociceptive systems has been proposed to contribute to this phenomenon. We have reported that the development o
Publikováno v:
British Journal of Pharmacology. 131:875-884
This study examined the effects of the peptide CGRP receptor antagonist CGRP(8-37) and the newly-developed non-peptide CGRP receptor antagonist BIBN4096BS for their potential to both inhibit the development and reverse tolerance to the antinociceptiv
Publikováno v:
Pain Research and Management, Vol 5, Iss 1, Pp 25-32 (2000)
Chronic opioid treatment results in the development of tolerance and physical dependence. The mechanisms underlying opioid tolerance and/or physical dependence are unclear. Recent studies suggest that opioid receptor or nociceptive, neural network-ba
Autor:
Rémi Quirion, Akiko Hosokawa, Khem Jhamandas, Maaja Sutak, Andrew H. Bell, Kelly J. Powell, Brian Milne
Publikováno v:
British Journal of Pharmacology. 127:631-644
1. This study examined the effects of the COX inhibitors, ketorolac and ibuprofen, and the NOS inhibitor L-NAME for their potential to both inhibit the development and reverse tolerance to the antinociceptive action of morphine. 2. Repeated administr
Publikováno v:
Journal of psychiatryneuroscience : JPN. 31(3)
The discovery of candidate susceptibility genes for schizophrenia and the generation of mice lacking proteins that reproduce biochemical processes that are disrupted in this mental illness offer unprecedented opportunities for improved modelling of t
Publikováno v:
The European journal of neuroscience. 18(6)
Chronic treatment with opioid drugs such as morphine leads to the development of tolerance, which manifests as a loss of drug potency. The mechanisms underlying this phenomenon are poorly understood, but recent evidence suggests that increased activi
Publikováno v:
Neuroscience. 120(3)
Calcitonin gene-related peptide (CGRP) is widely distributed in the central and peripheral nervous system. Its highly diverse biological activities are mediated via the G protein-coupled receptor that uniquely requires two accessory proteins for opti