Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kelly J. Pittman"'
Autor:
Alejandro L. Antonia, Kyle D. Gibbs, Esme D. Trahair, Kelly J. Pittman, Amelia T. Martin, Benjamin H. Schott, Jeffrey S. Smith, Sudarshan Rajagopal, J. Will Thompson, Richard Lee Reinhardt, Dennis C. Ko
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Clearance of intracellular pathogens, such as Leishmania (L.) major, depends on an immune response with well-regulated cytokine signaling. Here we describe a pathogen-mediated mechanism of evading CXCL10, a chemokine with diverse antimicrobial functi
Externí odkaz:
https://doaj.org/article/efb2ea97a83f446aaa4e38318def991a
Autor:
Benjamin Schott, Raphael H. Valdivia, Alejandro L. Antonia, Barbara S. Sixt, Dennis C. Ko, Liuyang Wang, Kelly J. Pittman, Alyson B. Barnes
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Susceptibility to infectious diseases is determined by a complex interaction between host and pathogen. For infections with the obligate intracellular bacterium Chlamydia trachomatis, variation in immune activation and disease presentation are regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76421e22f2ae10c46d2760c05af9515a
https://pubmed.ncbi.nlm.nih.gov/33106516
https://pubmed.ncbi.nlm.nih.gov/33106516
Autor:
Kelly J. Pittman, Alejandro L. Antonia, Esme D. Trahair, Alyson B. Barnes, Jeffrey S. Smith, J. W. Thompson, Kyle D. Gibbs, Dennis C. Ko, Richard Lee Reinhardt, Sudarshan Rajagopal, Monica I. Alvarez
Clearance of intracellular pathogens, such asLeishmania (L.) major, depends on a well-regulated adaptive T cell response. Here we describe a pathogen-encoded mechanism to alter T cell recruitment by suppressing CXCL10, a chemokine that recruits CD4+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f8312a0008e7227dd28b60d61055b1
Autor:
Stacy M. Horner, Jeffrey R. Barker, Soo Chan Lee, Robert J. Carroll, Mark R. DeLong, Joseph Heitman, Liuyang Wang, Kelly J. Pittman, Joshua C. Denny, Kyle D. Gibbs, Graham D. Williams, Tom Balmat, Anusha M. Gopalakrishnan, Andy Ingham, Alejandro L. Antonia, Dennis C. Ko, Raphael H. Valdivia, Ian B. Stanaway, David R. Crosslin, Gail P. Jarvik, Raul E. Salinas
Pathogens have been a strong driving force for natural selection. Therefore, understanding how human genetic differences impact infection-related cellular traits can mechanistically link genetic variation to disease susceptibility. Here we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a49984067e0e672b643409f84b457bc
https://europepmc.org/articles/PMC6093297/
https://europepmc.org/articles/PMC6093297/
Autor:
Johanna R. Elfenbein, Joshua T. Thaden, Mark K. Mammel, Kyle D. Gibbs, Liuyang Wang, W. Florian Fricke, Dennis C. Ko, Sarah L. Jaslow, Kelly J. Pittman, Gianna E. Hammer, Vance G. Fowler
Publikováno v:
Cell reports. 23(12)
Summary Salmonella enterica is an important foodborne pathogen that uses secreted effector proteins to manipulate host pathways to facilitate survival and dissemination. Different S. enterica serovars cause disease syndromes ranging from gastroenteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f782e1c4d4cb9b00a11ffa822bc80b
https://pubmed.ncbi.nlm.nih.gov/29924996
https://pubmed.ncbi.nlm.nih.gov/29924996
Autor:
Thomas N. Williams, Raul E. Salinas, Patricia Njuguna, J. W. Thompson, Neema Mturi, Christopher W. Woods, Emily R Ko, James J. Gilchrist, M.A. Moseley, Kelly J. Pittman, Dennis C. Ko, Matti Pirinen, Geoffrey S. Ginsburg, Douglas C. Rouse, Hill Avs., Liuyang Wang, Ephraim L. Tsalik, Laura G. Dubois, Raymond J. Langley, Sarah L. Jaslow, Salim Mwarumba, Anna Rautanen, Scott Jag.
Publikováno v:
Science Advances
The substrate of the methionine salvage pathway, methylthioadenosine, is a predictor of death in sepsis patients.
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis,
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3a44673bec4edae1f3ffeaddabe4d0
https://researchonline.lshtm.ac.uk/id/eprint/3716685/1/1602096.PMC5342653.pdf
https://researchonline.lshtm.ac.uk/id/eprint/3716685/1/1602096.PMC5342653.pdf
Publikováno v:
Infection and Immunity. 82:618-625
Toxoplasma gondii is an obligate intracellular parasite that forms a lifelong infection within the central nervous system of its host. The T. gondii genome encodes six members of the patatin-like phospholipase family; related proteins are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc496a4d74e1c89efca7bf7d4315ce8
https://doi.org/10.1128/iai.00444-13
https://doi.org/10.1128/iai.00444-13
Intrinsic to Toxoplasma gondii infection is the parasite-induced modulation of the host immune response, which ensures establishment of a chronic lifelong infection. This manipulation of the host immune response allows T. gondii to not only dampen th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f13c11e21e10b2c6a1276220bafe2f2
https://europepmc.org/articles/PMC5038082/
https://europepmc.org/articles/PMC5038082/
Autor:
JoDi Lynn Osborn, Bryan A. Stubblefield, Kelly J. Pittman, Chen Niu, Eric S. Gilbert, Chandan M. Robbins, Robert B. Simmons
Publikováno v:
FEMS Microbiology Ecology. 83:778-791
Escherichia coli produces biofilms in response to the small molecule autoinducer-2 (AI-2), a product of the LuxS enzyme. LuxS is part of the activated methyl cycle and could also affect biofilm development by AI-2-independent effects on metabolism. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29c5937d065bfdbada843de61df694d
https://doi.org/10.1111/1574-6941.12034
https://doi.org/10.1111/1574-6941.12034
Autor:
Kelly J. Pittman, Laura J. Knoll
Publikováno v:
Microbiology and molecular biology reviews : MMBR. 79(4)
SUMMARY Toxoplasma gondii represents one of the most common parasitic infections in the world. The asexual cycle can occur within any warm-blooded animal, but the sexual cycle is restricted to the feline intestinal epithelium. T. gondii is acquired t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250a114862917a9f1ebf53580b86c622
https://pubmed.ncbi.nlm.nih.gov/26335719
https://pubmed.ncbi.nlm.nih.gov/26335719