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pro vyhledávání: '"Kelly J. González-Lozano"'
Autor:
Rômulo Dias Novaes, Kelly J. González-Lozano, Ivo Santana Caldas, Andréa A.S. Mendonça, Elda Gonçalves-Santos, Reggiani Vilela Gonçalves, Lívia de Figueiredo Diniz, Thaiany G. Souza-Silva
Publikováno v:
Pharmacological Research. 158:104907
Phenothiazines inhibit major antioxidant defense mechanisms in trypanosomatids and exhibit potent cytotoxic effects in vitro. However, the relevance of these drugs in the treatment of Trypanosoma cruzi-induced acute myocarditis is poorly explored, es
Autor:
Reggiani Vilela Gonçalves, Rômulo Dias Novaes, Andréa A.S. Mendonça, Elda Gonçalves-Santos, Kelly J. González-Lozano, Lívia de Figueiredo Diniz, Ivo Santana Caldas, Thaiany G. Souza-Silva
Publikováno v:
International Immunopharmacology. 85:106611
While thioridazine (Tio) inhibits the antioxidant defenses of Trypanosoma cruzi, the gold standard antitrypanosomal drug benznidazole (Bz) has potent anti-inflammatory and pro-oxidant properties. The combination of these drugs has never been tested t