Výsledky vyhledávání - "Kelly J. Conn"

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

Autor: Kelly J. Conn, Isabel Carreras, Ana M. George, Ann C. McKee, Wenwu Gao, Richard E. Fine, John M. Wells, John A. Lynch, Patricia B. Eisenhauer, M. David Ullman

Publikováno v: Journal of Neuroscience Research. 83:1262-1270

Insulin degrading enzyme (IDE) is expressed in the brain and may play an important role there in the degradation of the amyloid beta peptide (Abeta). Our results show that cultured human cerebrovascular endothelial cells (HCECs), a primary component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae987982e10f92b70f6b55c046b966fe
https://doi.org/10.1002/jnr.20809

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Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells

Autor: Rosemary Garrett-Young, Kelly J. Conn, John M. Wells, Richard E. Fine, Isabel Carreras, Patricia B. Eisenhauer, M. David Ullman

Publikováno v: Journal of Neuroscience Research. 79:495-502

Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0fdca19807ef758e3df5c2ba1a1fb9
https://doi.org/10.1002/jnr.20374

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Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells

Autor: Hamant S. Thatte, Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John A. Lynch, John M. Wells, Ann C. McKee, Richard E. Fine, Wenwu Gao

Publikováno v: Neuroscience Letters. 371:6-11

Insulin degrading enzyme (IDE) is found in the cytosol, peroxisomes and plasma membrane of many cells. Although it preferentially cleaves insulin it can also cleave many other small proteins with diverse sequences including the monomeric form of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8768169bf09e1eddeccb8474e76a56d
https://doi.org/10.1016/j.neulet.2004.07.034

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Escherichia coli Shiga toxin 1 and TNF-α induce cytokine release by human cerebral microvascular endothelial cells

Autor: John M. Wells, Kelly J. Conn, Richard E. Fine, Patricia B Eisenhauer, David S. Newburg, Mary S Jacewicz, Omanand Koul

Publikováno v: Microbial Pathogenesis. 36:189-196

Infection with Shiga toxin (Stx)-producing Escherichia coli can lead to development of hemolytic uremic syndrome (HUS). Patients with severe HUS often exhibit central nervous system (CNS) pathology, which is thought to involve damage to brain endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e803c66482347dc9c3cf77eac463a6fd
https://doi.org/10.1016/j.micpath.2003.11.004

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[Untitled]

Autor: Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John M. Wells, Richard E. Fine, Michelle J. Larned

Publikováno v: Neurochemical Research. 28:1873-1881

cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdb53a644cfeaec1eb5f3a51d9689b05
https://doi.org/10.1023/a:1026179926780

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Monoclonal Antibodies Against the Human Metalloprotease EC 3.4.24.15 Label Neurofibrillary Tangles in Alzheimer's Disease Brain

Autor: Shyr-Te Ju, Michael Pietropaolo, Carmela R. Abraham, Kelly J. Conn

Publikováno v: Journal of Neurochemistry. 66:2011-2018

Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432f517f6ab6f7c3d7cf7adba4775fae
https://doi.org/10.1046/j.1471-4159.1996.66052011.x

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Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells

Autor: Patricia B. Eisenhauer, Richard E. Fine, M. David Ullman, Catherine McKeon-O'Malley, Wenwu Gao, John M. Wells, Kelly J. Conn

Publikováno v: Journal of Neuroscience Research. 68:755-760

Growth arrest DNA damage-inducible 153 (GADD153) expression was increased in 1-methyl-4-phenyl-pyridinium (MPP(+))-treated human SH-SY5Y neuroblastoma cells as determined by gene microarray analysis. GADD153 expression increased after 24 hr of MPP(+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e65fa56e59af7919669f909af69100f
https://doi.org/10.1002/jnr.10252

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Insulin-like Growth Factor-I Regulates Transcription of the Elastin Gene through a Putative Retinoblastoma Control Element

Autor: Donna E. Jensen, Judith Ann Foster, Muhammad M. Bashir, Kelly J. Conn, Celeste B. Rich, Marta R. Fontanilla, Joel Rosenbloom

Publikováno v: Journal of Biological Chemistry. 271:28853-28860

Previous studies have demonstrated that insulin-like growth factor-I (IGF-I) increases elastin gene transcription in aortic smooth muscle cells and that this up-regulation is accompanied by a loss of protein binding to the proximal promoter. Sp1 has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1a09d6f957ae87676cf2c931da1cc2b
https://doi.org/10.1074/jbc.271.46.28853

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Identification of full length β-amyloid precursor protein in human neuronal and non-neuronal cell culture supernatant: a possible extracellular source for the generation of Aβ

Autor: Kelly J. Conn, Gregoris Papastoitsis, Barbara Meckelein, Carmela R. Abraham

Publikováno v: Amyloid. 1:232-239

β protein (Aβ) which is deposited in the amyloid plaques and vasculature in brains of Alzheimer's Disease (AD) patients is a 39 to 43 amino acid peptide proteolytically derived from the amyloid precursor protein (AβPP). Three major isoforms are ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9aad9220a63093a4928a990965457376
https://doi.org/10.3109/13506129409146114

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Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology

Autor: Kelly J. Conn, Patricia B. Eisenhauer, M. David Ullman, John M. Wells, Richard E. Fine, Wenwu Gao, Ann C. McKee, Michael S. Lan

Publikováno v: Brain research. 1022(1-2)

Parkinson's disease (PD) is a slowly progressing neurodegenerative disorder with no clear etiology. Pathological hallmarks of the disease include the loss of dopaminergic neurons from the substantia nigra (SN) and the presence of Lewy bodies (LBs) (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cd935a3ea642a7d664a59fc63cddbf
https://pubmed.ncbi.nlm.nih.gov/15353226

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