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E-Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma
Autor:
Kerstin W. Sinkevicius, Patrizia Pessina, Roderick T. Bronson, Juliana Barrios, Manav Gupta, Carla F. Kim, Christine Fillmore Brainson, Kelly J. Bellaria
Publikováno v:
American journal of respiratory cell and molecular biology. 59(2)
Metastatic disease is the primary cause of death of patients with lung cancer, but the mouse models of lung adenocarcinoma do not accurately recapitulate the tumor microenvironment or metastatic disease observed in patients. In this study, we conditi