Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kelly J Bouchonville"'
Autor:
Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer
Publikováno v:
eLife, Vol 13 (2024)
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanis
Externí odkaz:
https://doaj.org/article/f486b24826a64551bd611deb78f24793
Autor:
Xinran Li, Jiaqi Zhou, Wenjuan Zhao, Qing Wen, Weijie Wang, Huipai Peng, Yuan Gao, Kelly J. Bouchonville, Steven M. Offer, Kuiming Chan, Zhiquan Wang, Nan Li, Haiyun Gan
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 87-100 (2022)
Proximity labeling catalyzed by promiscuous enzymes, such as APEX2, has emerged as a powerful approach to characterize multiprotein complexes and protein–protein interactions. However, current methods depend on the expression of exogenous fusion pr
Externí odkaz:
https://doaj.org/article/644a5eceee4a410299fef3ebf625378f
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Externí odkaz:
https://doaj.org/article/accd85a0450f4044aac0532324b3811d
Autor:
Saba Ghaffari, Casey Hanson, Remington E. Schmidt, Kelly J. Bouchonville, Steven M. Offer, Saurabh Sinha
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Metastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for metastasis remain poorly understood. Multi-omics approaches hold great promise for addressin
Externí odkaz:
https://doaj.org/article/3b06df1e6d194294a86ab1748ec3cb2c
Autor:
Saba Ghaffari, Kelly J. Bouchonville, Ehsan Saleh, Remington E. Schmidt, Steven M. Offer, Saurabh Sinha
BackgroundDifferential gene expression in bulk transcriptomics data can reflect change of transcript abundance within a cell type and/or change in the proportion of cell types within the sample. Expression deconvolution methods can help differentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60978ff93f982d27d6aeb58312301c91
https://doi.org/10.1101/2022.10.25.513800
https://doi.org/10.1101/2022.10.25.513800
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02514ec87a4205865c350b7cbc6c4824
http://www.sciencedirect.com/science/article/pii/S266700542100003X
http://www.sciencedirect.com/science/article/pii/S266700542100003X
Autor:
Haiyun Gan, Nan Li, Zhiquan Wang, Steven M. Offer, Kelly J. Bouchonville, Huipai Peng, Weijie Wang, Qing Wen, Wenjuan Zhao, Jiaqi Zhou, Xinran Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa038aebe7e3d3ba14fc9d9b93e823d6
https://doi.org/10.15252/rc.2022449711
https://doi.org/10.15252/rc.2022449711
Autor:
Jin Zhou, Ning Li, Wenjuan Zhao, Hong Peng, Kelly J. Bouchonville, Zhanwen Wang, Haiyun Gan, Xutong Li, W. H. Wang, Qing Wen, Steven M. Offer
Proximity labeling catalyzed by promiscuous enzymes, such as APEX2, has emerged as a powerful approach to characterize multiprotein complexes and protein-protein interactions. However, current methods depend on the expression of exogenous fusion prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff9436fbea0cc7ec40a71994b36460f9
https://doi.org/10.1101/2021.03.05.434178
https://doi.org/10.1101/2021.03.05.434178
Autor:
Remington E. Schmidt, Saba Ghaffari, Steven M. Offer, Kelly J. Bouchonville, Casey Hanson, Saurabh Sinha
Publikováno v:
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Background Metastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for metastasis remain poorly understood. Multi-omics approaches hold great promise for addressing this ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e8cfa13b7674e6fb08ed31303cd690
https://doi.org/10.1186/s13059-020-02213-x
https://doi.org/10.1186/s13059-020-02213-x
Autor:
Robert B. Diasio, Qian Nie, Steven M. Offer, Kelly J. Bouchonville, Erin E. Tapper, Colbren S. Trogstad-Isaacson, Shikshya Shrestha
Publikováno v:
Cancer Research. 78:3893-3893
5-Fluorouracil (5-FU) has remained a widely prescribed anti-cancer drug for decades. However, 5-FU–based treatments show inter-individual variability, with up to 34% of 5-FU–treated patients developing severe (grade 3+) adverse toxicity. Dihydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a9fa8559744744d00d78a770b03581
https://doi.org/10.1158/1538-7445.am2018-3893
https://doi.org/10.1158/1538-7445.am2018-3893