Výsledky vyhledávání - "Kelly I. Griffey"

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

Autor: Joseph P. Tizzano, Darryle D. Schoepp, Kelly I. Griffey

Publikováno v: Pharmacology Biochemistry and Behavior. 73:367-374

The fear-potentiated startle paradigm has been characterized for drugs that act via ionotropic (NMDA and AMPA/kainate receptor) glutamate receptor mechanisms. Previous studies have shown that the potent systemically active mGlu2/3 receptor agonist, L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d4115d979fea415e759e11a1e0188e
https://doi.org/10.1016/s0091-3057(02)00850-x

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Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

Autor: Bryan G. Johnson, Joseph P. Tizzano, Michael P. Johnson, Kelly I. Griffey, Darryle D. Schoepp, Rebecca A. Wright, John R. Harris, Gerald Kelly, Ann E. Kingston, Mary Jo Chamberlain, Rosemarie Tomlinson, Barry Peter Clark, Richard S. Baker

Publikováno v: Neuroscience Letters. 330:127-130

A series of novel group I metabotropic glutamate receptor (mGlu) antagonists have been designed on the basis of the 4-carboxyphenylglycine pharmacophore. The compounds are either mGlu1 receptor selective or equipotent for both mGlu1 and mGlu5 recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cbdd09122fcc04534fbba2a2c6b34a
https://doi.org/10.1016/s0304-3940(02)00751-6

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The Selective Estrogen Receptor Modulator, Raloxifene: Reproductive Assessments Following Preimplantation Exposure in Mated Female Rats 11These studies were conducted in accordance with the Food and Drug Administration 'Good Laboratory Practice Regulations for Nonclinical Laboratory Studies.' CRF Part 58, 1978

Autor: J. Buelke-Sam, Paul C Francis, Clarke David O, Kelly I. Griffey

Publikováno v: Reproductive Toxicology. 12:247-259

Raloxifene is a nonsteroidal, selective estrogen receptor modulator being developed for postmenopausal osteoporosis. As part of an integrated reproductive toxicity assessment, two studies were conducted in which raloxifene was administered orally to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48143feb7e9e1232d0d9c88a76566e7f
https://doi.org/10.1016/s0890-6238(98)00009-4

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Synthesis of the Four Isomers of 4-Aminopyrrolidine-2,4-dicarboxylate: Identification of a Potent, Highly Selective, and Systemically-Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase

Autor: Darryle D. Schoepp, Joseph P. Tizzano, Trevor J. Howe, Jonathan W. Paschal, James A. Monn, David Lodge, Rebecca A. Wright, Jack B. Campbell, Ann Bond, Bryan G. Johnson, Craig R. Salhoff, Larry A. Spangle, Matthew John Valli, Kelly I. Griffey

Publikováno v: Journal of Medicinal Chemistry. 39:2990-3000

The four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC) were prepared and evaluated for their effects at glutamate receptors in vitro. (2R,4R)-APDC (2a), an aza analog of the nonselective mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarbox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783218551741efe9fef70e83335349e8
https://doi.org/10.1021/jm9601765

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Induction or protection of limbic seizures in mice by mGluR subtype selective agonists

Autor: Kelly I. Griffey, D D Schoepp, Joseph P. Tizzano

Publikováno v: Neuropharmacology. 34:1063-1067

The behavioral consequences of metabotropic glutamate receptor (mGluR) activation were investigated following intracerebral administration of the mGluR selective agonists (RS)3,5-dihydroxyphenyl-glycine (3,5-DHPG), (1S,3R)-1-aminocyclopentane-1,3-dic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112346179a8c775e171967f31259c7c4
https://doi.org/10.1016/0028-3908(95)00083-i

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

Autor: Kenneth W. Perry, Darryle D. Schoepp, Kelly I. Griffey, Bryan G. Johnson, James A. Monn, David L. McKinzie, Joseph P. Tizzano, Jeffrey M. Witkin, Karen M. Knitowski, Craig R. Salhoff, Linda M. Rorick-Kehn

Publikováno v: Psychopharmacology. 193(1)

Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor agonists, might provide therapeutic benefits in many psychiatric disorders including schizophrenia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3e40edec0b314d0016d84613bc65f5
https://pubmed.ncbi.nlm.nih.gov/17384937

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(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity

Autor: Ivan Collado, Eric D. Moher, Joseph P. Tizzano, Concepcion Pedregal, David W. Hoard, T. Rosario Gonzalez, Jaime Blanco-Urgoiti, Rebecca A. Wright, Darryle Darwin Schoepp, Javier Pérez-Castells, Kelly I. Griffey, Alicia Marcos, Ana Belén Bueno, Ann E. Kingston, Bryan G. Johnson

Publikováno v: Journal of medicinal chemistry. 47(2)

The asymmetric synthesis and biological activity of (2S,1‘S,2‘R,3‘R)-2-(2‘-carboxy-3‘-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3‘ substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1da05542dd760a151e9a35936f1754a
https://pubmed.ncbi.nlm.nih.gov/14711315

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Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

Autor: Joseph P. Tizzano, Michael P. Clay, Xia Li, Terry D. Lindstrom, Phil Skolnick, Kelly I. Griffey

Publikováno v: Neuropharmacology. 40(8)

LY392098 is a member of a novel class of biarylpropylsulfonamides that potentiates AMPA receptor-mediated responses both in vitro and in vivo. In this study, the effects of LY392098 were evaluated in two "behavioral despair" models (the forced swim a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a61d4a0d2af8bd17aa42a6dd9e6ab19
https://pubmed.ncbi.nlm.nih.gov/11406194

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