Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kelly Horne Donaldson"'
Publikováno v:
Tetrahedron Letters. 50:1399-1402
N-Substituted 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazoles were conveniently accessed via microwave-assisted synthesis. Subsequent Suzuki–Miyaura cross-coupling with heteroaryl halides proceeded to give a wide variety of hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af7af0ba74e5f233b1e18890b8577a3
https://doi.org/10.1016/j.tetlet.2009.01.087
https://doi.org/10.1016/j.tetlet.2009.01.087
Autor:
Kimberly G. Petrov, Thomas R. Caferro, Octerloney B. McDonald, David W. Rusnak, Dana E. Vanderwall, Kelly Horne Donaldson, Tara Renae Rheault, David E. Uehling, Lisa M. Shewchuk, Scott Howard Dickerson, Robert J. Mullin, Michael D. Gaul, Aaron S. Goetz, Glenn M. Spehar, Anne T. Truesdale, Edgar R. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:817-820
Two new series of potent and selective dual EGFR/ErbB-2 kinase inhibitors derived from novel thienopyrimidine cores have been identified. Isomeric thienopyrimidine cores were evaluated as isosteres for a 4-anilinoquinazoline core and several analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a62e1d36d5f76869f6a2a75d7237e2
https://doi.org/10.1016/j.bmcl.2008.12.011
https://doi.org/10.1016/j.bmcl.2008.12.011
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1683-1686
When treated with concentrated hydrochloric acid or heated beyond its melting point, the versatile thioimine 2 2-mercaptobenzhydrylidenamine was unexpectedly converted to the title ring system. Also, this imine can be converted to 3-phenyl-1,2-benzis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b61177788bd4c4f6a17a0db1cf0583a
https://doi.org/10.1002/jhet.5570320603
https://doi.org/10.1002/jhet.5570320603
Publikováno v:
ChemInform. 27
When treated with concentrated hydrochloric acid or heated beyond its melting point, the versatile thioimine 2 2-mercaptobenzhydrylidenamine was unexpectedly converted to the title ring system. Also, this imine can be converted to 3-phenyl-1,2-benzis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3450b0b6b4b5f1d4761956bcb56bfce
https://doi.org/10.1002/chin.199620149
https://doi.org/10.1002/chin.199620149
Autor:
Jeffrey R. Jackson, Ronda G. Davis-Ward, C. Webb Andrews, Ramesh Bambal, Jennifer G. Badiang-Alberti, Tara Renae Rheault, Kelly Horne Donaldson, Mui Cheung
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors' physiochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0e57818be1d878a7fa01a0e04bce7c
https://pubmed.ncbi.nlm.nih.gov/20594842
https://pubmed.ncbi.nlm.nih.gov/20594842
Publikováno v:
ChemInform. 40
N-Substituted 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazoles were conveniently accessed via microwave-assisted synthesis. Subsequent Suzuki–Miyaura cross-coupling with heteroaryl halides proceeded to give a wide variety of hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a300dcf211d158ebf612e25df6ed721
https://doi.org/10.1002/chin.200929122
https://doi.org/10.1002/chin.200929122
Autor:
Sarva M. Tadepalli, Alex G. Waterson, Perry Scott Brignola, Scott Howard Dickerson, Robert J. Mullin, Thomas R. Caferro, Craig D. Wagner, Hamilton D. Dickson, Dana E. Vanderwall, Kimberly G. Petrov, John C. Ulrich, Michael D. Gaul, Lisa M. Shewchuk, Anne M. Hassell, Kelly Horne Donaldson, Edgar R. Wood, David E. Uehling, Jon D. Williams, Ronald L. Brashear, Barry R. Keith, Wendy L. White, David W. Rusnak, Byron Ellis, Robert J. Griffin, Michael J. Reno
Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent bond between the terminal carbon of the acetylene moiety and the sulfhydryl group of Cys-803 at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee325f04de0f7f4e5e90c473b3e261b
https://europepmc.org/articles/PMC2268535/
https://europepmc.org/articles/PMC2268535/
Autor:
David N. Deaton, Kim K. Adkison, Tula Milliken, Kelly Horne Donaldson, Walter L Faison, Robert Hart, David E. Uehling, Neal F. Cariello, Kathleen K. Brown, Mark A. Paulik, Mary E. Lancaster, Esther Y. Chao, Bryan W. Sherman, Conrad Cowan, Jasmine Lin, Elizabeth E. Sugg, Barry G. Shearer
Publikováno v:
Journal of medicinal chemistry. 49(9)
The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta position with a benzoic acid or a pyridyl carboxylate is described. Several of the analogues (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23efecdde36afb7f8fbfc1945a62e8b
https://pubmed.ncbi.nlm.nih.gov/16640337
https://pubmed.ncbi.nlm.nih.gov/16640337
Autor:
David N. Deaton, Mark A. Paulik, Frank Lee, Kim K. Adkison, Elizabeth E. Sugg, Robert Hart, Clifton E. Hyman, Bryan W. Sherman, Timothy A. True, B.E. Reitter, David Barrett, Conrad Cowan, Mary E. Lancaster, Robert G. Hughes, Kelly Horne Donaldson, David E. Uehling
Publikováno v:
Journal of medicinal chemistry. 45(3)
Starting from phenethanolamine aniline leads 3a and 3b, we have identified a series of functionally potent and selective beta(3) adrenergic receptor (AR) agonists containing acylsulfonamide, sulfonylsulfonamide, or sulfonylurea groups within the anil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd2c81aa3f421786049ce5ef971b53e
https://pubmed.ncbi.nlm.nih.gov/11806709
https://pubmed.ncbi.nlm.nih.gov/11806709