Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kelly G. Bryant"'
Autor:
M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, Dario C. Altieri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Mitochondria have a controversial role in cancer. Here, the authors demonstrate the reprogramming of a neuronal network of mitochondrial trafficking in tumor cells, and identify Syntaphilin as a key protein that suppresses organelle dynamics thereby
Externí odkaz:
https://doaj.org/article/a83307e942fa4962afc59efab303f2dc
Autor:
Dario C. Altieri, David W. Speicher, Andrew R. Cohen, Dmitry I. Gabrilovich, Lucia R. Languino, Hsin-Yao Tang, Andrew V. Kossenkov, Eui Tae Kim, M. Cecilia Caino, Kelly G. Bryant, Ekta Agarwal, Jae Ho Seo
Regulation of SNPH ubiquitination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5af4d587c264ea35941a2f50a32284
https://doi.org/10.1158/0008-5472.22418802.v1
https://doi.org/10.1158/0008-5472.22418802.v1
Autor:
Dario C. Altieri, David W. Speicher, Andrew R. Cohen, Dmitry I. Gabrilovich, Lucia R. Languino, Hsin-Yao Tang, Andrew V. Kossenkov, Eui Tae Kim, M. Cecilia Caino, Kelly G. Bryant, Ekta Agarwal, Jae Ho Seo
Pathway analysis of SNPH-associated proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d44b4b89a83f94410cc59293d986a1
https://doi.org/10.1158/0008-5472.22418781
https://doi.org/10.1158/0008-5472.22418781
Autor:
Dario C. Altieri, David W. Speicher, Andrew R. Cohen, Dmitry I. Gabrilovich, Lucia R. Languino, Hsin-Yao Tang, Andrew V. Kossenkov, Eui Tae Kim, M. Cecilia Caino, Kelly G. Bryant, Ekta Agarwal, Jae Ho Seo
Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and invasion. Although this may suppress metastasis, the regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fec29d6d866969186b69012c2594b40
https://doi.org/10.1158/0008-5472.c.6510225.v1
https://doi.org/10.1158/0008-5472.c.6510225.v1
Autor:
Dario C. Altieri, David W. Speicher, Andrew R. Cohen, Dmitry I. Gabrilovich, Lucia R. Languino, Hsin-Yao Tang, Andrew V. Kossenkov, Eui Tae Kim, M. Cecilia Caino, Kelly G. Bryant, Ekta Agarwal, Jae Ho Seo
Contents of Supplementary Figures ans Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d3a995d69c3c4726b22043dd25b2f
https://doi.org/10.1158/0008-5472.22418784
https://doi.org/10.1158/0008-5472.22418784
Autor:
Wayne E. Childers, Khaled M. Elokely, Magid Abou-Gharbia, Rogelio Martinez, Dario C. Altieri, Steven Grant, Andrew V. Kossenkov, Young Chan Chae, John Gordon, Kelly G. Bryant
Publikováno v:
Oncotarget
Reprogramming of mitochondrial functions sustains tumor growth and may provide therapeutic opportunities. Here, we targeted the protein folding environment in mitochondria by coupling a purine-based inhibitor of the molecular chaperone Heat Shock Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fc5f1b5d0d77ffaa99104ea5405121
https://doi.org/10.18632/oncotarget.23097
https://doi.org/10.18632/oncotarget.23097
Autor:
Cristina Martelli, Marco Locatelli, Dario C. Altieri, Jagadish C. Ghosh, Luisa Ottobrini, Lucia R. Languino, Bonsu Ku, Jae Ho Seo, Giovanni Lucignani, Silvano Bosari, David W. Speicher, Hsin Yao Tang, M. Cecilia Caino, Young Chan Chae, Irene Bertolini, Valentina Vaira, Andrew V. Kossenkov, Sofia Lisanti, Kelly G. Bryant
Publikováno v:
Cancer Cell. 30:257-272
Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms are not completely understood. Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5922588fbf419286bb72d65d359aa985
https://doi.org/10.1016/j.ccell.2016.07.004
https://doi.org/10.1016/j.ccell.2016.07.004
Autor:
Peter A. Humphrey, Marie E. Robert, Jae Ho Seo, Qin Liu, Michael J. Hwang, Mary Ann Melnick, Dario C. Altieri, Kelly G. Bryant
Publikováno v:
Am J Pathol
Easily accessible biomarkers that may inform on the metastatic potential of localized prostate cancer are urgently needed. Herein, we show that syntaphilin (SNPH), a molecule originally identified as a negative regulator of mitochondrial dynamics in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaf95983946f81628b08e1d3322be49
https://pubmed.ncbi.nlm.nih.gov/31079810
https://pubmed.ncbi.nlm.nih.gov/31079810
Autor:
Jae Ho Seo, Andrew R. Cohen, Valentina Vaira, Andrew V. Kossenkov, M. Cecilia Caino, Lucia R. Languino, Eric Wait, Angeline Aguinaldo, Silvano Bosari, Stefano Ferrero, Kelly G. Bryant, Dmitry I. Gabrilovich, Dario C. Altieri, James Hayden, Annamaria Morotti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b82fb6ab30e7206f1c103ca028c31
https://doi.org/10.1038/ncomms13730
https://doi.org/10.1038/ncomms13730
Autor:
Dario C. Altieri, Gordon B. Mills, Lucia R. Languino, David S. Garlick, Andrew V. Kossenkov, Louise C. Showe, Sofia Lisanti, Kelly G. Bryant, Michele Tavecchio, Yiling Lu
Publikováno v:
The Journal of biological chemistry. 291(48)
Protein homeostasis, or proteostasis, is required for mitochondrial function, but its role in cancer is controversial. Here we show that transgenic mice expressing the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) in the prostate develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12185007a958693b29236d2239b9b8e2
https://pubmed.ncbi.nlm.nih.gov/27754870
https://pubmed.ncbi.nlm.nih.gov/27754870