Výsledky vyhledávání - "Kelly F. Meijsen"

Akademický článek

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis MiceSummary

Autor: Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)

Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbios

Externí odkaz: https://doaj.org/article/0a415309b75c4917861654a9a812df3d

Zobrazit plný text záznamu

Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers

Autor: Marcel J C, Bijvelds, Floris J M, Roos, Kelly F, Meijsen, Henk P, Roest, Monique M A, Verstegen, Hettie M, Janssens, Luc J W, van der Laan, Hugo R, de Jonge

Publikováno v: Journal of Cystic Fibrosis, 21(3), 537-543. Elsevier

Background: In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR)-dependent bicarbonate secretion precipitates the accumulation of viscous mucus in the lumen of respiratory and gastrointestinal epithelial tissues. We investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0955b9e7749c092c1aa328854aa6984
https://pure.eur.nl/en/publications/4db722ee-f0b8-47d4-be18-49316f5ed366

Zobrazit plný text záznamu

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice

Autor: Hugo R. de Jonge, Kelly F. Meijsen, Johan W. Jonker, Pauline T. Ikpa, Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Marcela Doktorova

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Cellular and molecular gastroenterology and hepatology, 9(1), 47-60. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 9(1), 47-60. Elsevier Inc.

Background & Aims The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8055077ad92962df0418235c07c4f6f5
https://research.rug.nl/en/publications/34117206-9fb3-4deb-93c6-97b1fd66ffab

Zobrazit plný text záznamu

A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations

Autor: Kelly F. Meijsen, Hugo R. de Jonge, Antje Ballauff, Anke H M van Vugt, Roderick H. J. Houwen, Manuel B Bryant, Thomas Müller, Sabine Middendorp, Tanja Restin, Marcel J. C. Bijvelds, Andreas R. Janecke, Bart G. P. Koot

Publikováno v: Clinical and Translational Gastroenterology, 12(11):e00427. Nature Publishing Group
van Vugt, A H M, Bijvelds, M J C, de Jonge, H R, Meijsen, K F, Restin, T, Bryant, M B, Ballauff, A, Koot, B, Müller, T, Houwen, R H J, Janecke, A R & Middendorp, S 2021, ' A Potential Treatment of Congenital Sodium Diarrhea in Patients With Activating GUCY2C Mutations ', CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, vol. 12, no. 11, pp. e00427 . https://doi.org/10.14309/ctg.0000000000000427
Clinical and translational gastroenterology, 12(11). Nature Publishing Group
Clinical and Translational Gastroenterology
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 12(11). Nature Publishing Group

INTRODUCTION: Gain-of-function mutations in guanylyl cyclase C (GCC) result in persistent diarrhea with perinatal onset. We investigated a specific GCC inhibitor, SSP2518, for its potential to treat this disorder. METHODS: We investigated the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d3192ebcfb634acea304772d3b318e
https://pure.eur.nl/en/publications/476a3967-0cd2-4270-92cc-95c7bcb17260

Zobrazit plný text záznamu

Transcriptome analysis of the distal small intestine of Cftr null mice

Autor: Kalyan Dulla, Pauline T. Ikpa, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Marcel J. C. Bijvelds, Hugo R. de Jonge

Publikováno v: Genomics, 112(2), 1139-1150. Academic Press

Cystic fibrosis (CF) is caused by mutations in the gene encoding the CFTR anion channel. Loss of CFTR function in pancreatic, biliary and intestinal epithelia, severely affects gastrointestinal function. Transcriptome analysis indicated the activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268191e0adc8855fc2b2b3e50ee1582f
https://pure.eur.nl/en/publications/c492eab8-921d-4390-928c-7ae2cf643362

Zobrazit plný text záznamu

Selective inhibition of intestinal guanosine 3,5-cyclic monophosphate signaling by small-molecule protein kinase inhibitors

Autor: Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Karine Smans, Kelly F. Meijsen, Ann Hellemans, Gary Tresadern, Joris H. De Maeyer, Jean-Pierre Bongartz, Hugo R. de Jonge, Luc Ver Donck, Jan A.J. Schuurkes

Publikováno v: Journal of Biological Chemistry, 293(21), 8173-8181. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry

The guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis. Here, we report the discovery of small-molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1ee4a8f9967179af8984be752279ac
https://hdl.handle.net/1765/107349

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání