Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kelly E. Leon"'
Publikováno v:
Medical Sciences, Vol 11, Iss 1, p 5 (2022)
Defects in how excess nutrients are stored as triglycerides can result in several diseases including obesity, heart disease, and diabetes. Understanding the genes responsible for normal lipid homeostasis will help understand the pathogenesis of these
Externí odkaz:
https://doaj.org/article/0814e91c6c474d60b0975a5e4aeece16
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e05097- (2020)
While therapies targeting deficiencies in the homologous recombination (HR) pathway are emerging as the standard treatment for high grade serous ovarian cancer (HGSOC) patients, this strategy is limited to the ~50% of patients with a deficiency in th
Externí odkaz:
https://doaj.org/article/7a7fa06a1dc4461aa0ed0a40af313203
Autor:
Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1971-1980.e8 (2019)
Summary: Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle pro
Externí odkaz:
https://doaj.org/article/43188544f0f744368b8635d3e2d2aa3b
Autor:
Beth L. Worley, Yeon Soo Kim, Jennifer Mardini, Rameez Zaman, Kelly E. Leon, Piyushi Gupta Vallur, Asvelt Nduwumwami, Joshua I. Warrick, Patrick F. Timmins, Joshua P. Kesterson, Rébécca Phaëton, Nam Y. Lee, Vonn Walter, Lauren Endres, Karthikeyan Mythreye, Katherine M. Aird, Nadine Hempel
Publikováno v:
Redox Biology, Vol 25, Iss , Pp - (2019)
Ovarian cancer remains the most lethal gynecologic malignancy, and is primarily diagnosed at late stage when considerable metastasis has occurred in the peritoneal cavity. At late stage abdominal cavity ascites accumulation provides a tumor-supportin
Externí odkaz:
https://doaj.org/article/0ee39ed6b42940489efa251bb7ae9eb6
Publikováno v:
Life, Vol 11, Iss 4, p 309 (2021)
p16INK4A (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known ab
Externí odkaz:
https://doaj.org/article/c51b5a42596d48518a7053e35ed0338e
Autor:
Katherine M. Aird, Nathaniel W. Snyder, Benjamin G. Bitler, Yuka Imamura, Jordan M. Newell, Kelly E. Leon, Raquel Buj, Erika S. Dahl
Knockdown of IDH1 induces senescence in Ovcar10 cells but does not increase SASP gene expression. Related to Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd094ccc741b252529cd752ba3813837
https://doi.org/10.1158/1541-7786.22512411.v1
https://doi.org/10.1158/1541-7786.22512411.v1
Supplementary Data from Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer
Autor:
Katherine M. Aird, Nathaniel W. Snyder, Benjamin G. Bitler, Yuka Imamura, Jordan M. Newell, Kelly E. Leon, Raquel Buj, Erika S. Dahl
Compiled Supplementary Data File
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed87d7fecd8cedf2ca7b6fe2163e79d
https://doi.org/10.1158/1541-7786.22512405.v1
https://doi.org/10.1158/1541-7786.22512405.v1
Autor:
Katherine M. Aird, Nathaniel W. Snyder, Benjamin G. Bitler, Yuka Imamura, Jordan M. Newell, Kelly E. Leon, Raquel Buj, Erika S. Dahl
Primer sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1259d83905793685cf15b3f76fa5bba1
https://doi.org/10.1158/1541-7786.22512402.v1
https://doi.org/10.1158/1541-7786.22512402.v1
Autor:
Katherine M. Aird, Nathaniel W. Snyder, Benjamin G. Bitler, Yuka Imamura, Jordan M. Newell, Kelly E. Leon, Raquel Buj, Erika S. Dahl
Epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer. High-grade serous carcinoma (HGSC) is the most frequently diagnosed and lethal histosubtype of EOC. A significant proportion of patients with HGSC relapse with chemoresistant diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a08f336370fe27a7b4b15471c4e80f4
https://doi.org/10.1158/1541-7786.c.6540234.v1
https://doi.org/10.1158/1541-7786.c.6540234.v1
Publikováno v:
Aging (Albany NY)
Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ff12ddf66d9a9e8be55ab2b6721803
https://doi.org/10.18632/aging.202640
https://doi.org/10.18632/aging.202640