Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kelly E. Caudle"'
Autor:
Kelly E. Caudle, Katrin Sangkuhl, Michelle Whirl‐Carrillo, Jesse J. Swen, Cyrine E. Haidar, Teri E. Klein, Roseann S. Gammal, Mary V. Relling, Stuart A. Scott, Daniel L. Hertz, Henk‐Jan Guchelaar, Andrea Gaedigk
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 116-124 (2020)
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC)
Externí odkaz:
https://doaj.org/article/eaaeaa1c4346425da8183e2137c63c57
Autor:
Sarah G. Whaley, Kelly E. Caudle, Lucia Simonicova, Qing Zhang, W. Scott Moye-Rowley, P. David Rogers
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
ABSTRACT The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis. Fluconazole resistance in this yeast is almost exclusively d
Externí odkaz:
https://doaj.org/article/29a87add80ba496aa18e8316ed68c869
Publikováno v:
Pharmacogenomics. 24:183-186
Publikováno v:
Annual Review of Genomics and Human Genetics. 23:449-473
Pharmacogenomic testing can be an effective tool to enhance medication safety and efficacy. Pharmacogenomically actionable medications are widely used, and approximately 90–95% of individuals have an actionable genotype for at least one pharmacogen
Autor:
Chad A. Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl, J. Kevin Hicks, Jeffrey R. Strawn, Ajeet B. Singh, Gualberto Ruaño, Daniel J. Mueller, Evangelia Eirini Tsermpini, Jacob T. Brown, Gillian C. Bell, J. Steven Leeder, Andrea Gaedigk, Stuart A. Scott, Teri E. Klein, Kelly E. Caudle, Jeffrey R. Bishop
Publikováno v:
Clinical Pharmacology & Therapeutics.
Autor:
Rhonda M. Cooper‐DeHoff, Mikko Niemi, Laura B. Ramsey, Jasmine A. Luzum, E. Katriina Tarkiainen, Robert J. Straka, Li Gong, Sony Tuteja, Russell A. Wilke, Mia Wadelius, Eric A. Larson, Dan M. Roden, Teri E. Klein, Sook Wah Yee, Ronald M. Krauss, Richard M. Turner, Latha Palaniappan, Andrea Gaedigk, Kathleen M. Giacomini, Kelly E. Caudle, Deepak Voora
Publikováno v:
Clinical pharmacology and therapeutics, vol 111, iss 5
Clinical Pharmacology & Therapeutics
Clinical Pharmacology & Therapeutics
Statins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin-associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long-term effecti
Autor:
Craig R. Lee, Jasmine A. Luzum, Katrin Sangkuhl, Roseann S. Gammal, Marc S. Sabatine, Charles Michael Stein, David F. Kisor, Nita A. Limdi, Yee Ming Lee, Stuart A. Scott, Jean‐Sébastien Hulot, Dan M. Roden, Andrea Gaedigk, Kelly E. Caudle, Teri E. Klein, Julie A. Johnson, Alan R. Shuldiner
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:959-967
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibiti
Autor:
Caroline Flora Samer, Larisa H. Cavallari, Andrew A. Monte, Andrew A. Somogyi, Rachel Huddart, Evan D. Kharasch, Kelly E. Caudle, Gualberto Ruaño, J. Steven Leeder, Andrea Gaedigk, Sara L. Van Driest, Cynthia A. Prows, Kristine R. Crews, Teri E. Klein, Todd C. Skaar, Henry M. Dunnenberger, Cyrine E. Haidar, Daniel J. Müller, John T. Callaghan, Mohamed Nagy, Katrin Sangkuhl
Publikováno v:
Clin Pharmacol Ther
Clinical Pharmacology and Therapeutics (2021)
Clinical Pharmacology and Therapeutics (2021)
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have been studied for an association with the c
Publikováno v:
Genet Med
Autor:
James M. Hoffman, Roseann S. Gammal, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Mary V. Relling
Publikováno v:
Clin Pharmacol Ther
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC; www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide