Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kelly D. Pyles"'
Autor:
Alexander Piening, Emily Ebert, Carter Gottlieb, Niloufar Khojandi, Lindsey M. Kuehm, Stella G. Hoft, Kelly D. Pyles, Kyle S. McCommis, Richard J. DiPaolo, Stephen T. Ferris, Elise Alspach, Ryan M. Teague
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Obesity is a well-established risk factor for human cancer, yet the underlying mechanisms remain elusive. Immune dysfunction is commonly associated with obesity but whether compromised immune surveillance contributes to cancer susceptibility
Externí odkaz:
https://doaj.org/article/cd1f556956cf44109479901a6087aca1
Autor:
Martin C. Sharpe, Kelly D. Pyles, Taylor Hallcox, Dakota R. Kamm, Michaela Piechowski, Bryan Fisk, Carolyn J. Albert, Danielle H. Carpenter, Barbara Ulmasov, David A. Ford, Brent A. Neuschwander-Tetri, Kyle S. McCommis, PhD
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 4, Pp 558-572 (2023)
Background and Aims: Polymorphisms near the membrane bound O-acyltransferase domain containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver (NASH), and nonalcoholic fatty liver disease (NAFLD)/NASH may decrease MBOAT7 expres
Externí odkaz:
https://doaj.org/article/7425424d086845348870dd196c829045
Autor:
Shubha Shakya, Kelly D. Pyles, Carolyn J. Albert, Rakesh P. Patel, Kyle S. McCommis, David A. Ford
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102557- (2023)
Neutrophil and airway epithelial cell interactions are critical in the inflammatory response to viral infections including respiratory syncytial virus, Sendai virus, and SARS-CoV-2. Airway epithelial cell dysfunction during viral infections is likely
Externí odkaz:
https://doaj.org/article/5594c408ecac4dcf9e52d985f74d1e3c
Autor:
Lamees Hegazy, Lauren E. Gill, Kelly D. Pyles, Christopher Kaiho, Sophia Kchouk, Brian N. Finck, Kyle S. McCommis, Bahaa Elgendy
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 365 (2022)
The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has emerged as a drug target for treating a variety of human conditions. A heterodimer of two proteins, MPC1 and MPC2, comprises the functional MPC compl
Externí odkaz:
https://doaj.org/article/a66280e760704a9eb41b66b1865dfb89
Autor:
Ryan M. Teague, Richard J. DiPaolo, Kyle S. McCommis, Maureen J. Donlin, Kevin A. Bockerstett, Mary L. Preuss, Afton M. Nelson, Kelly D. Pyles, Thomas P. Burris, Kristine Griffett, Nicole R. McLaughlin, Simone C. Geraud, Lauryn E. Klevorn, Alexander Piening, Niloufar Khojandi, Lindsey M. Kuehm
Checkpoint blockade immunotherapy relies on the empowerment of the immune system to fight cancer. Why some patients fail to achieve durable clinical responses is not well understood, but unique individual factors such as diet, obesity, and related me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3d2e1554fae29479dda4a9946eec7d
https://doi.org/10.1158/2326-6066.c.6550453.v1
https://doi.org/10.1158/2326-6066.c.6550453.v1
Autor:
Ryan M. Teague, Richard J. DiPaolo, Kyle S. McCommis, Maureen J. Donlin, Kevin A. Bockerstett, Mary L. Preuss, Afton M. Nelson, Kelly D. Pyles, Thomas P. Burris, Kristine Griffett, Nicole R. McLaughlin, Simone C. Geraud, Lauryn E. Klevorn, Alexander Piening, Niloufar Khojandi, Lindsey M. Kuehm
Supplemental Figs S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273c20ce0d1830f4a1861a92fdb13653
https://doi.org/10.1158/2326-6066.22543891.v1
https://doi.org/10.1158/2326-6066.22543891.v1
Autor:
Martin C. Sharpe, Kelly D. Pyles, Taylor Hallcox, Dakota R. Kamm, Michaela Piechowski, Bryan Fisk, Carolyn J. Albert, Danielle H. Carpenter, Barbara Ulmasov, David A. Ford, Brent A. Neuschwander-Tetri, Kyle S. McCommis
Background & AimsGenetic analyses of human NASH have revealed polymorphisms near the membrane bound O-acyl transferase domain containing 7 (MBOAT7) gene associated with worsened liver injury. NAFLD/NASH also appears to decrease MBOAT7 expression or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529b41d4d615a28e30718231ff4cb80b
https://doi.org/10.1101/2022.03.24.485677
https://doi.org/10.1101/2022.03.24.485677
Autor:
Kyle S. McCommis, Jerry R. Colca, Dakota R. Kamm, Laura N. Healy, Martin C. Sharpe, Kelly D. Pyles
Publikováno v:
The Journal of Biological Chemistry
Insulin sensitizers and incretin mimetics are antidiabetic agents with vastly different mechanisms of action. Thiazolidinedione (TZD) insulin sensitizers are associated with weight gain, whereas glucagon-like peptide-1 receptor agonists can induce we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be842022a0f9bc0e85ea8d47048c5426
https://pubmed.ncbi.nlm.nih.gov/34022222
https://pubmed.ncbi.nlm.nih.gov/34022222
Autor:
Jerry R. Colca, Laura N. Healy, Kyle S. McCommis, Kelly D. Pyles, Dakota R. Kamm, Martin C. Sharpe
Aims/hypothesisInsulin sensitizers and incretin mimetics are antidiabetic agents with vastly different mechanisms of action. Additionally, while thiazolidinedione (TZD) insulin sensitizers are associated with the side-effect of weight gain, glucagon-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e812442208f27d33e7a581c449075420
https://doi.org/10.1101/2020.12.10.420190
https://doi.org/10.1101/2020.12.10.420190
Autor:
Attila Kovacs, Kelly D. Pyles, Olga Ilkayeva, Trevor M. Shew, M. Todd King, Carla J. Weinheimer, Richard L. Veech, Timothy R. Koves, Brian J. DeBosch, Dakota R. Kamm, Brian N. Finck, Richard W. Gross, Kyle S. McCommis, Deborah M. Muoio
The myocardium is metabolically flexible and can use fatty acids, glucose, lactate/pyruvate, ketones, or amino acids to fuel mechanical work. However, impaired metabolic flexibility is associated with cardiac dysfunction in conditions including diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc65355ed0061e463575dc8d97d70e2